Abstract：
Capsaicin is a chili peppers extract, genus Capsicum, commonly used as a food spice. Since ancient times, Capsaicin has been used as a \"homeopathic remedy\" for treating a wild range of pathological conditions but without any scientific knowledge about its action. Several studies have demonstrated its potentiality in cardiovascular, nephrological, nutritional, and other medical fields. Capsaicin exerts its actions thanks to the bond with transient receptor potential vanilloid subtype 1 (TRPV1). TRPV1 is a nociceptive receptor, and its activation starts with a neurosensitive impulse, responsible for a burning pain sensation. However, constant local application of Capsaicin desensitized neuronal cells and leads to relief from neuropathic pain. In this review, we analyze the potential adjuvant role of Capsaicin in the treatment of different pathological conditions either in internal medicine or dentistry. Moreover, we present our experience in five patients affected by oro-facial pain consequent to post-traumatic trigeminal neuropathy, not responsive to any remedy, and successfully treated with topical application of Capsaicin. The topical application of Capsaicin is safe, effective, and quite tolerated by patients. For these reasons, in addition to the already-proven beneficial actions in the internal field, it represents a promising method for the treatment of neuropathic oral diseases.
摘要：
辣椒素是一种辣椒提取物，辣椒属,常用作食品香料。自古以来,辣椒素已被用作治疗各种病理状况的“顺势疗法”，但对其作用没有任何科学知识。几项研究已经证明了它在心血管疾病中的潜力，肾脏病学，营养,和其他医疗领域。辣椒素由于与瞬时受体电位香草素亚型1（TRPV1）的结合而发挥其作用。TRPV1是一种伤害性受体，它的激活始于神经敏感的冲动，负责灼痛的感觉。然而,持续局部应用辣椒素脱敏神经元细胞，并导致缓解神经性疼痛。在这次审查中,我们分析了辣椒素在内科或牙科治疗不同病理状况中的潜在辅助作用。此外，我们介绍了我们在五名患者中的经验，这些患者受到创伤后三叉神经病变后的口面部疼痛的影响，不回应任何补救措施，并通过局部应用辣椒素成功治疗。辣椒素的局部应用是安全的，有效,患者相当耐受。由于这些原因,除了内部领域已经证明的有益行动之外，它代表了治疗神经性口腔疾病的一种有前途的方法。
