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Abstract：
The assessment of fibrosis in chronic liver diseases using non-invasive methods is an important topic in hepatology. The aim of this study is to identify patients with non-alcoholic fatty liver disease (NAFLD) and advanced liver fibrosis by establishing correlations between biological/ultrasound markers and non-invasively measured liver stiffness. This study enrolled 116 patients with non-alcoholic fatty liver disease, which were evaluated clinically, biologically, and by ultrasound. Liver fibrosis was quantified by measuring liver stiffness by shear wave elastography (SWE). Multiple correlation analysis of predictors of liver fibrosis identified a number of clinical, biological, and ultrasound parameters (BMI, blood glucose, albumin, platelet count, portal vein diameter, bipolar spleen diameter) that are associated with advanced liver fibrosis in patients with non-alcoholic fatty liver disease. The correlations between the degree of liver fibrosis and the risk values of some serological and ultrasound markers obtained in our study could be useful in clinical practice for the identification of advanced fibrosis in patients with NAFLD.
摘要：
使用非侵入性方法评估慢性肝病中的纤维化是肝病学的重要课题。这项研究的目的是通过建立生物/超声标志物和非侵入性测量的肝硬度之间的相关性来识别非酒精性脂肪性肝病（NAFLD）和晚期肝纤维化患者。这项研究纳入了116例非酒精性脂肪性肝病患者，经过临床评估，生物学，还有超声波.通过剪切波弹性成像（SWE）测量肝脏硬度来量化肝纤维化。肝纤维化的预测因子的多重相关性分析确定了一些临床，生物，和超声参数(BMI，血糖，白蛋白,血小板计数,门静脉直径,双极脾直径）与非酒精性脂肪肝患者的晚期肝纤维化有关。肝纤维化程度与我们研究中获得的一些血清学和超声标志物的风险值之间的相关性可能在临床实践中用于鉴定NAFLD患者的晚期纤维化。
