Abstract：
Approaches to estimating clearance rates, an important metric of human papillomavirus (HPV) clearance, for HPV groupings differ between studies. We aimed to identify the approaches used in the literature for estimating grouped HPV clearance rates. We investigated whether these approaches resulted in different estimations, using data from existing studies.
In this systematic review, we included articles that reported clearance rates of HPV groupings. We identified approaches to data in the HAVANA cohort, comprising adolescent girls, and the H2M cohort, comprising men who have sex with men. We estimated clearance rates for six HPV groupings (bivalent-, quadrivalent- and nonavalent vaccine-related, and low-risk, high-risk, and any HPV).
From 26 articles, we identified 54 theoretically possible approaches to estimating clearance rates. These approaches varied regarding definitions of clearance events and person-time, and prevalence or incidence of infections included in the analysis. Applying the nine most-used approaches to the HAVANA ( n = 1,394) and H2M ( n = 745) cohorts demonstrated strong variation in clearance rate estimates depending on the approach used. For example, for grouped high-risk HPV in the H2M cohort, clearance rates ranged from 52.4 to 120.0 clearances/1000 person-months. Clearance rates also varied in the HAVANA cohort, but differences were less pronounced, ranging from 24.1 to 57.7 clearances/1000 person-months.
Varied approaches from the literature for estimating clearance rates of HPV groupings yielded different clearance rate estimates in our data examples. Estimates also varied between study populations. We advise clear reporting of methodology and urge caution in comparing clearance rates between studies.
In this systematic review, we included articles that reported clearance rates of HPV groupings. We identified approaches to data in the HAVANA cohort, comprising adolescent girls, and the H2M cohort, comprising men who have sex with men. We estimated clearance rates for six HPV groupings (bivalent-, quadrivalent- and nonavalent vaccine-related, and low-risk, high-risk, and any HPV).
From 26 articles, we identified 54 theoretically possible approaches to estimating clearance rates. These approaches varied regarding definitions of clearance events and person-time, and prevalence or incidence of infections included in the analysis. Applying the nine most-used approaches to the HAVANA ( n = 1,394) and H2M ( n = 745) cohorts demonstrated strong variation in clearance rate estimates depending on the approach used. For example, for grouped high-risk HPV in the H2M cohort, clearance rates ranged from 52.4 to 120.0 clearances/1000 person-months. Clearance rates also varied in the HAVANA cohort, but differences were less pronounced, ranging from 24.1 to 57.7 clearances/1000 person-months.
Varied approaches from the literature for estimating clearance rates of HPV groupings yielded different clearance rate estimates in our data examples. Estimates also varied between study populations. We advise clear reporting of methodology and urge caution in comparing clearance rates between studies.
摘要：
背景：估算清除率的方法，人乳头瘤病毒（HPV）清除率的重要指标，对于HPV分组，研究之间存在差异。我们旨在确定文献中用于估计分组HPV清除率的方法。我们调查了这些方法是否会导致不同的估计，使用现有研究的数据。
方法：在这篇系统综述中，我们纳入了报道HPV组清除率的文章.我们确定了HAVANA队列中的数据方法，包括青春期的女孩，和H2M队列，包括与男人发生性关系的男人。我们估计了六个HPV组的清除率（二价-，四价和非价疫苗相关，低风险,高风险,和任何HPV）。
结果：来自26篇文章，我们确定了54种理论上可能的方法来估计清除率.这些方法在清除事件和人员时间的定义上有所不同，以及分析中包括的感染患病率或发病率。将九种最常用的方法应用于HAVANA（n=1,394）和H2M（n=745）队列表明，根据所使用的方法，清除率估计值存在很大差异。例如,对于H2M队列中分组的高危HPV，清关率从52.4到120.0清关/1000人-月不等。HAVANA队列的清除率也有所不同，但是差异不太明显，范围从24.1到57.7许可/1000人-月。
结论：在我们的数据示例中，用于估计HPV组清除率的文献中的各种方法产生了不同的清除率估计值。研究人群之间的估计也有所不同。我们建议明确报告方法，并敦促在比较研究之间的清除率时要谨慎。
方法：在这篇系统综述中，我们纳入了报道HPV组清除率的文章.我们确定了HAVANA队列中的数据方法，包括青春期的女孩，和H2M队列，包括与男人发生性关系的男人。我们估计了六个HPV组的清除率（二价-，四价和非价疫苗相关，低风险,高风险,和任何HPV）。
结果：来自26篇文章，我们确定了54种理论上可能的方法来估计清除率.这些方法在清除事件和人员时间的定义上有所不同，以及分析中包括的感染患病率或发病率。将九种最常用的方法应用于HAVANA（n=1,394）和H2M（n=745）队列表明，根据所使用的方法，清除率估计值存在很大差异。例如,对于H2M队列中分组的高危HPV，清关率从52.4到120.0清关/1000人-月不等。HAVANA队列的清除率也有所不同，但是差异不太明显，范围从24.1到57.7许可/1000人-月。
结论：在我们的数据示例中，用于估计HPV组清除率的文献中的各种方法产生了不同的清除率估计值。研究人群之间的估计也有所不同。我们建议明确报告方法，并敦促在比较研究之间的清除率时要谨慎。
