PDF(Pubmed)
Abstract：
Background: Occupational cancers can be avoided by removing dangerous chemicals from the workplace or limiting occupational exposure. Approximately, 10 major risk factors account for 85% of all occupational cancers. This scoping review study aimed to determine the most important chemical carcinogens related to 5 known occupational cancers. Methods: In this scoping review, we followed Arksey and O\'Malley\'s 5-step framework. Four databases (PubMed, Web of Science, Google Scholar, Scopus) were systematically reviewed for relevant published papers from January 2000 to September 2021. Studies were included in this scoping review, which examined the effect of carcinogenic (definite and probable) chemical exposures on 5 known occupational cancers (lung, bladder, laryngeal, leukemia, and liver). We reported the types of occupational carcinogens, the geographical diversity of studies, extraction of relative risks (RRs), hazard ratios (HRs), or odds ratios (ORs), and identified gaps in the existing literature. Results: The highest number of studies was related to lung cancer (LC) (n = 26), bladder cancer (BC) (n = 11), laryngeal cancer (LaC) (n = 8), leukemia (LeC) (n = 3), and primary liver cancer (PLC) (n = 2), respectively. Most studies were performed in France and Canada (n = 8), Germany (n = 4), Finland (n = 3), Netherlands (n = 2), and Finland (n = 2), respectively. Furthermore, the most common occupational chemical carcinogens associated with the 5 known occupational cancers were asbestos, benzene, crystalline silica, polycyclic aromatic hydrocarbons (PAH), and diesel motor exhausts (DME). Conclusion: Although the attributable risk of occupational cancers in developing countries is much higher, a small proportion of studies were performed in these countries.
摘要：
背景：可以通过从工作场所去除危险化学品或限制职业暴露来避免职业性癌症。大约,10个主要危险因素占所有职业性癌症的85%。这项范围审查研究旨在确定与5种已知职业癌症相关的最重要的化学致癌物。方法：在这篇范围界定综述中，我们遵循了Arksey和O'Malley的5步框架。四个数据库(PubMed，WebofScience,谷歌学者，Scopus）在2000年1月至2021年9月期间对相关已发表论文进行了系统审查。研究包括在这次范围审查中，它检查了致癌（明确和可能的）化学暴露对5种已知的职业性癌症（肺癌，膀胱,喉,白血病,和肝脏）。我们报道了职业性致癌物的类型,研究的地理多样性，提取相对风险(RR)，危险比(HR)，或赔率比(OR)，并确定了现有文献中的差距。结果：与肺癌（LC）相关的研究数量最多（n=26），膀胱癌（BC）（n=11），喉癌（LaC）（n=8），白血病（LeC）（n=3），和原发性肝癌（PLC）（n=2），分别。大多数研究在法国和加拿大进行（n=8），德国（n=4），芬兰（n=3），荷兰（n=2），芬兰（n=2），分别。此外，与5种已知职业癌症相关的最常见的职业化学致癌物是石棉，苯,结晶二氧化硅，多环芳烃（PAH），和柴油机排气（DME）。结论：尽管发展中国家职业性癌症的归因风险要高得多，一小部分研究是在这些国家进行的.
