PDF(Pubmed)
Abstract：
UNASSIGNED: Herpes simplex virus (HSV) reactivation occasionally develops in the early postoperative period after microvascular decompression (MVD) for trigeminal neuralgia (TN). Therefore, the present study investigated the clinical features of this phenomenon.
UNASSIGNED: The study cohort comprised 200 patients with 125 women aged between 17 and 90 years (median age, 66 years) who underwent MVD for TN between January 2010 and December 2020. Characteristics were compared between patients with and without HSV reactivation and clinical features were analyzed.
UNASSIGNED: Twenty patients had HSV reactivation: herpes labialis in 18 and herpes zoster (final diagnosis) in 2. A multivariate analysis revealed independent correlations between postoperative HV reactivation and a previous history of herpes labialis (odds ratios [OR]: 6.32, P = 0.0003) and reoperation for recurrent or persistent pain (OR: 5.06, P = 0.0211). No significant differences were observed in pain relief, postoperative facial numbness, or Barrow Neurological Institute Pain Intensity/Facial Numbness Scores in the past follow-up between patients with and without HSV reactivation. HSV reactivation manifested at a median of the 4th postoperative day (1-10 days) and its location was not related to the preoperative distribution of facial pain. All patients were treated with local acyclovir and were completely cured within 1-2 weeks.
UNASSIGNED: HSV reactivation occurred in 10% of patients after MVD including 1% of herpes zoster. A previous history of herpes labialis and reoperation was identified as risk factors for reactivation. Symptoms were completely cured by antiviral drugs within 1-2 weeks. It is important to note that cases of herpes zoster may be confused with cases of HSV after MVD.
UNASSIGNED: The study cohort comprised 200 patients with 125 women aged between 17 and 90 years (median age, 66 years) who underwent MVD for TN between January 2010 and December 2020. Characteristics were compared between patients with and without HSV reactivation and clinical features were analyzed.
UNASSIGNED: Twenty patients had HSV reactivation: herpes labialis in 18 and herpes zoster (final diagnosis) in 2. A multivariate analysis revealed independent correlations between postoperative HV reactivation and a previous history of herpes labialis (odds ratios [OR]: 6.32, P = 0.0003) and reoperation for recurrent or persistent pain (OR: 5.06, P = 0.0211). No significant differences were observed in pain relief, postoperative facial numbness, or Barrow Neurological Institute Pain Intensity/Facial Numbness Scores in the past follow-up between patients with and without HSV reactivation. HSV reactivation manifested at a median of the 4th postoperative day (1-10 days) and its location was not related to the preoperative distribution of facial pain. All patients were treated with local acyclovir and were completely cured within 1-2 weeks.
UNASSIGNED: HSV reactivation occurred in 10% of patients after MVD including 1% of herpes zoster. A previous history of herpes labialis and reoperation was identified as risk factors for reactivation. Symptoms were completely cured by antiviral drugs within 1-2 weeks. It is important to note that cases of herpes zoster may be confused with cases of HSV after MVD.
摘要：
未经证实：三叉神经痛（TN）微血管减压（MVD）术后早期偶尔会发生单纯疱疹病毒（HSV）再激活。因此,本研究调查了这种现象的临床特征。
UNASSIGNED：该研究队列包括200名患者，其中125名女性，年龄在17至90岁之间（中位年龄，66年)，在2010年1月至2020年12月期间接受了TN的MVD。比较有和没有HSV再激活的患者的特征，并分析临床特征。
UNASSIGNED：20例HSV再激活：唇疱疹18例，带状疱疹（最终诊断）2例。多变量分析显示，术后HV再激活与既往唇疱疹病史（比值比[OR]：6.32，P=0.0003）与复发性或持续性疼痛再次手术（OR：5.06，P=0.0211）之间存在独立相关性。在疼痛缓解方面没有观察到显著差异，术后面部麻木,或BarrowNeurologicalInstitute疼痛强度/面部麻木评分在过去的随访中有和没有HSV再激活的患者之间。HSV再激活表现在术后第4天（1-10天）的中位数，其位置与术前面部疼痛的分布无关。所有患者均接受局部阿昔洛韦治疗，并在1-2周内完全治愈。
UNASSIGNED：MVD后10％的患者发生HSV再激活，包括1％的带状疱疹。先前的唇疱疹病史和再次手术被确定为再激活的危险因素。症状在1-2周内通过抗病毒药物完全治愈。重要的是要注意，带状疱疹病例可能与MVD后的HSV病例相混淆。
UNASSIGNED：该研究队列包括200名患者，其中125名女性，年龄在17至90岁之间（中位年龄，66年)，在2010年1月至2020年12月期间接受了TN的MVD。比较有和没有HSV再激活的患者的特征，并分析临床特征。
UNASSIGNED：20例HSV再激活：唇疱疹18例，带状疱疹（最终诊断）2例。多变量分析显示，术后HV再激活与既往唇疱疹病史（比值比[OR]：6.32，P=0.0003）与复发性或持续性疼痛再次手术（OR：5.06，P=0.0211）之间存在独立相关性。在疼痛缓解方面没有观察到显著差异，术后面部麻木,或BarrowNeurologicalInstitute疼痛强度/面部麻木评分在过去的随访中有和没有HSV再激活的患者之间。HSV再激活表现在术后第4天（1-10天）的中位数，其位置与术前面部疼痛的分布无关。所有患者均接受局部阿昔洛韦治疗，并在1-2周内完全治愈。
UNASSIGNED：MVD后10％的患者发生HSV再激活，包括1％的带状疱疹。先前的唇疱疹病史和再次手术被确定为再激活的危险因素。症状在1-2周内通过抗病毒药物完全治愈。重要的是要注意，带状疱疹病例可能与MVD后的HSV病例相混淆。
