Abstract：
OBJECTIVE: To evaluate the reproducibility of the 2D shear wave elastography (2D-SWE) method and to identify the prognostic factors of breast lesions.
METHODS: In this prospective study, 44 female patients were consecutively included from January 2020 to September 2021. All patients showing visible masses at B-mode ultrasound underwent to clinical evaluation, followed by qualitative and quantitative 2D-SWE by two different operators with over 15-year and 2-year experience, respectively. Subsequently, patients underwent to surgical treatment after core needle biopsy. Reproducibility of qualitative and quantitative 2D-SWE was evaluated by Cohen\'s kappa and intraclass correlation coefficient (ICC). Clinical, imaging, and histopathological data and 2D-SWE evaluations were analysed with Spearman\'s rank correlation test.
RESULTS: The mean age of the patients was 55 years ± 12. The mean histological and ultrasound tumour size of were 23.1 mm ± 13.2 and 17.2 mm ± 10.2, respectively. The interobserver agreement showed a good reproducibility limited to the qualitative evaluation colour maps (Cohen\'s kappa = 0.603) and to the quantitative evaluation E ratio (ICC = 0.771). Correlation analysis between the ultrasound and 2D-SWE values and the clinical-pathological parameters showed a significant relationship between E ratio and Elston-Ellis grading (P < 0.030) and between tumour size and Elston-Ellis grading (P < 0.041).
CONCLUSIONS: The 2D-SWE has shown good reproducibility among operators with different experience. It could be a promising tool in the evaluation of some prognostic factors in ultrasound visible breast cancer.
METHODS: In this prospective study, 44 female patients were consecutively included from January 2020 to September 2021. All patients showing visible masses at B-mode ultrasound underwent to clinical evaluation, followed by qualitative and quantitative 2D-SWE by two different operators with over 15-year and 2-year experience, respectively. Subsequently, patients underwent to surgical treatment after core needle biopsy. Reproducibility of qualitative and quantitative 2D-SWE was evaluated by Cohen\'s kappa and intraclass correlation coefficient (ICC). Clinical, imaging, and histopathological data and 2D-SWE evaluations were analysed with Spearman\'s rank correlation test.
RESULTS: The mean age of the patients was 55 years ± 12. The mean histological and ultrasound tumour size of were 23.1 mm ± 13.2 and 17.2 mm ± 10.2, respectively. The interobserver agreement showed a good reproducibility limited to the qualitative evaluation colour maps (Cohen\'s kappa = 0.603) and to the quantitative evaluation E ratio (ICC = 0.771). Correlation analysis between the ultrasound and 2D-SWE values and the clinical-pathological parameters showed a significant relationship between E ratio and Elston-Ellis grading (P < 0.030) and between tumour size and Elston-Ellis grading (P < 0.041).
CONCLUSIONS: The 2D-SWE has shown good reproducibility among operators with different experience. It could be a promising tool in the evaluation of some prognostic factors in ultrasound visible breast cancer.
摘要：
目的：评估二维剪切波弹性成像（2D-SWE）方法的可重复性，并确定乳腺病变的预后因素。
方法：在这项前瞻性研究中，从2020年1月至2021年9月连续纳入44例女性患者。所有B超显示可见肿块的患者均接受临床评估，其次是定性和定量2D-SWE由两个不同的运营商超过15年和2年的经验，分别。随后，患者在芯针活检后接受手术治疗。定性和定量2D-SWE的可重复性通过Cohen的κ和组内相关系数（ICC）进行评估。临床,成像,组织病理学数据和2D-SWE评价采用Spearman秩相关检验进行分析。
结果：患者的平均年龄为55岁±12岁。平均组织学和超声肿瘤大小分别为23.1mm±13.2和17.2mm±10.2。观察者之间的协议显示出良好的可重复性，仅限于定性评估彩色图（Cohen的kappa=0.603）和定量评估E比率（ICC=0.771）。超声和2D-SWE值与临床病理参数之间的相关性分析显示，E比值与Elston-Ellis分级（P<0.030）以及肿瘤大小与Elston-Ellis分级（P<0.041）之间存在显着关系。
结论：2D-SWE在具有不同经验的操作员中显示出良好的可重复性。它可能是评估超声可见乳腺癌某些预后因素的有希望的工具。
方法：在这项前瞻性研究中，从2020年1月至2021年9月连续纳入44例女性患者。所有B超显示可见肿块的患者均接受临床评估，其次是定性和定量2D-SWE由两个不同的运营商超过15年和2年的经验，分别。随后，患者在芯针活检后接受手术治疗。定性和定量2D-SWE的可重复性通过Cohen的κ和组内相关系数（ICC）进行评估。临床,成像,组织病理学数据和2D-SWE评价采用Spearman秩相关检验进行分析。
结果：患者的平均年龄为55岁±12岁。平均组织学和超声肿瘤大小分别为23.1mm±13.2和17.2mm±10.2。观察者之间的协议显示出良好的可重复性，仅限于定性评估彩色图（Cohen的kappa=0.603）和定量评估E比率（ICC=0.771）。超声和2D-SWE值与临床病理参数之间的相关性分析显示，E比值与Elston-Ellis分级（P<0.030）以及肿瘤大小与Elston-Ellis分级（P<0.041）之间存在显着关系。
结论：2D-SWE在具有不同经验的操作员中显示出良好的可重复性。它可能是评估超声可见乳腺癌某些预后因素的有希望的工具。
