Abstract：
This study aimed to map systemic alterations predisposing to oral squamous cell carcinoma (OSCC) onset. This review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. Five databases were used to access (1) reports of OSCC co-occurring in patients with systemic conditions, (2) prevalence of OSCC among these patients, and (3) clinicopathological profiles. Data from more than 1 million patients worldwide showed that Fanconi\'s anemia, xeroderma pigmentosum, dyskeratosis congenital, chronic fatigue syndrome, and patients post bone marrow transplantation (BMT) present increased risk for OSCC development. The overall prevalence of OSCC in syndromic patients and post-BMT were 0.65% (95% CI = 0.13-3.11, p < 0.01) and 5.83% (95% CI = 0.00-30.90, p < 0.01), respectively. The certainty of the evidence was moderate. This study demonstrated that some systemic conditions predispose to OSCC. These results present an impact on the screening of OSCC in systemically compromised patients.
摘要：
这项研究旨在绘制易感口腔鳞状细胞癌（OSCC）发病的系统性改变。本综述是根据系统评价和荟萃分析的首选报告项目进行的。五个数据库被用于访问（1）OSCC在全身疾病患者中同时发生的报告，(2)OSCC在这些患者中的患病率，（3）临床病理特征。来自全球100多万患者的数据显示，范可尼的贫血，着色性干皮病,先天性角化障碍，慢性疲劳综合征,骨髓移植（BMT）后患者出现OSCC的风险增加。OSCC在综合征患者和BMT后的总体患病率分别为0.65%(95%CI=0.13-3.11,p<0.01)和5.83%(95%CI=0.00-30.90,p<0.01),分别。证据的确定性是中等的。这项研究表明，一些系统条件易患OSCC。这些结果对系统性受损患者的OSCC筛查具有影响。
