METHODS: A total of 139 first-diagnosed, drug-naïve patients with depression and 55 healthy controls (HCs) were included in the cross-sectional study. The levels of erythrocyte membrane FAs were compared and then the correlation between clinical symptoms and fatty acid levels in depression was investigated.
RESULTS: Compared to HCs, patients with depression had higher C18:1n9t (z = -2.033, p = 0.042), C20:4n6 (z = -2.104, p = 0.035), C20:3n6 (z = -2.104, p = 0.035) and n-6 polyunsaturated fatty acids (PUFAs) (z = -2.127, p = 0.033), whereas the levels of C18:1n9c (z = -3.348, p = 0.001) were significantly lower. Higher C20:3n6, C20:4n6, C18:1n9t and n-6 PUFAs levels were associated with higher severity of depressive and anxiety symptoms in patients with depression, and the correlation remained after adjusting for the related confounding factors (p < 0.05).
CONCLUSIONS: Patients with first-diagnosed, drug-naïve depression show abnormal erythrocyte fatty acid composition. Trans fatty acids (TFAs) and n-6 PUFAs levels are closely related to clinical characteristics of depression. This study indicated that increased n-6 PUFAs and TFAs are characteristic changes of first-diagnosed, drug-naïve depression.
方法:共139例首次诊断,本横断面研究纳入了未接受药物治疗的抑郁症患者和55名健康对照(HCs).比较红细胞膜FAs水平,然后研究抑郁症临床症状与脂肪酸水平之间的相关性。
结果:与HC相比,抑郁症患者的C18:1n9t较高(z=-2.033,p=0.042),C20:4n6(z=-2.104,p=0.035),C20:3n6(z=-2.104,p=0.035)和n-6多不饱和脂肪酸(PUFA)(z=-2.127,p=0.033),而C18:1n9c(z=-3.348,p=0.001)的水平显着降低。较高的C20:3n6,C20:4n6,C18:1n9t和n-6PUFAs水平与抑郁症患者抑郁和焦虑症状的严重程度有关,校正相关混杂因素后,相关性仍然存在(p<0.05)。
结论:首次诊断的患者,药物初治抑郁症显示红细胞脂肪酸组成异常。反式脂肪酸(TFA)和n-6PUFA水平与抑郁症的临床特征密切相关。这项研究表明,n-6PUFA和TFA的增加是首次诊断的特征性变化,药物天真抑郁症。