Abstract：
BACKGROUND: Syphilis is known as the \"great imitator\" because of its polymorphic clinical manifestations. Condyloma lata are an uncommon mucocutaneous manifestation of secondary syphilis, generally localized in intertriginous areas, such as the genitals and anus. Extragenital localization of condyloma lata is considered unusual.
METHODS: A case study of extra-genital condylomata is presented. To contextualise the case, a literature review of extra-genital condylomata lata was subsequently undertaken. The authors searched MEDLINE/PubMed, Scopus and Excerpta Medica/EMBASE English-language sources using the following keywords: \"condyloma lata\", \"condylomata lata\", and \"condyloma latum\".
RESULTS: Thirty-five papers (from 1940 to 2021) describing an extra-anogenital localization of condyloma lata were found and are summarized in Table 1. Patients were mainly males (82.1%), with a mean age of 31.9 years. Most of them showed other manifestations of secondary syphilis (53.9%). In a minority of cases (39.0%), concomitant anogenital condyloma lata were present, thus making the diagnosis easier. The toe web localization was the most documented (26.2%) followed by the oral cavity (23.8%).
CONCLUSIONS: In the presence of extra-genital condyloma lata, the differential diagnosis is not always clear, especially when no other muco-cutaneous lesions are observed. In the case of eroded or wet lesions involving any cutaneous fold, associated or not with other cutaneous manifestations, a sexual history should be obtained, and syphilis must be considered.
METHODS: A case study of extra-genital condylomata is presented. To contextualise the case, a literature review of extra-genital condylomata lata was subsequently undertaken. The authors searched MEDLINE/PubMed, Scopus and Excerpta Medica/EMBASE English-language sources using the following keywords: \"condyloma lata\", \"condylomata lata\", and \"condyloma latum\".
RESULTS: Thirty-five papers (from 1940 to 2021) describing an extra-anogenital localization of condyloma lata were found and are summarized in Table 1. Patients were mainly males (82.1%), with a mean age of 31.9 years. Most of them showed other manifestations of secondary syphilis (53.9%). In a minority of cases (39.0%), concomitant anogenital condyloma lata were present, thus making the diagnosis easier. The toe web localization was the most documented (26.2%) followed by the oral cavity (23.8%).
CONCLUSIONS: In the presence of extra-genital condyloma lata, the differential diagnosis is not always clear, especially when no other muco-cutaneous lesions are observed. In the case of eroded or wet lesions involving any cutaneous fold, associated or not with other cutaneous manifestations, a sexual history should be obtained, and syphilis must be considered.
摘要：
背景：梅毒因其多态的临床表现而被称为“伟大的模仿者”。湿疣是继发性梅毒的一种罕见的粘膜皮肤表现，通常位于中间区域，如生殖器和肛门。尖锐湿疣的婚外定位被认为是不寻常的。
方法：以生殖器外尖锐湿疣为例进行研究。为了说明案件的背景，随后对生殖器外尖锐湿疣进行了文献综述.作者搜索了MEDLINE/PubMed，Scopus和ExcerptaMedica/EMBASE使用以下关键字的英语来源：\"尖锐湿疣\"，“尖锐湿疣”，和“尖锐湿疣”。
结果：发现了35篇论文（从1940年到2021年），这些论文描述了尖锐湿疣的生殖器外定位，并总结在表1中。患者主要为男性（82.1%），平均年龄31.9岁.其中大多数表现为继发性梅毒的其他表现（53.9％）。在少数情况下（39.0％），同时存在肛门生殖器尖锐湿疣，从而使诊断更容易。脚趾网定位是记录最多的（26.2％），其次是口腔（23.8％）。
结论：在存在外生殖器湿疣的情况下，鉴别诊断并不总是很清楚，特别是当没有观察到其他粘膜皮肤病变时。在涉及任何皮肤褶皱的侵蚀或湿润病变的情况下，与其他皮肤表现有关或无关，应该获得性史，梅毒必须考虑。
方法：以生殖器外尖锐湿疣为例进行研究。为了说明案件的背景，随后对生殖器外尖锐湿疣进行了文献综述.作者搜索了MEDLINE/PubMed，Scopus和ExcerptaMedica/EMBASE使用以下关键字的英语来源：\"尖锐湿疣\"，“尖锐湿疣”，和“尖锐湿疣”。
结果：发现了35篇论文（从1940年到2021年），这些论文描述了尖锐湿疣的生殖器外定位，并总结在表1中。患者主要为男性（82.1%），平均年龄31.9岁.其中大多数表现为继发性梅毒的其他表现（53.9％）。在少数情况下（39.0％），同时存在肛门生殖器尖锐湿疣，从而使诊断更容易。脚趾网定位是记录最多的（26.2％），其次是口腔（23.8％）。
结论：在存在外生殖器湿疣的情况下，鉴别诊断并不总是很清楚，特别是当没有观察到其他粘膜皮肤病变时。在涉及任何皮肤褶皱的侵蚀或湿润病变的情况下，与其他皮肤表现有关或无关，应该获得性史，梅毒必须考虑。
