Abstract：
Obstructive sleep apnea (OSA), with daytime drowsiness, nocturnal hypoxia, could result in systemic inflammation and oxidative damage. We hypothesize that parental OSA, with chronic systemic inflammation and oxidative stress, might contribute to children\'s neurodevelopmental disorders, such as ADHD.
By linking National Birth Registry with the National Health Insurance Research Database, Taiwan, we identified 2006-2015 birth cohort, which comprised 1,723,873 singleton live births, and conducted a nested case-control study. We included children with ADHD and compared them with non-ADHD controls matched with ADHD case on index date. Conditional logistic regression was utilized to calculate adjusted odds ratio (aOR) when investigating the association between parental diseases with risk of ADHD in their offspring.
The aOR (95% CI) of offspring\'s ADHD was 1.758 (1.458-2.119) with paternal OSA and 2.159 (1.442-3.233) with maternal OSA. The subgroup analysis revealed different effects of parental diseases among children\'s gender.
Our study demonstrates an association in parental OSA and offspring ADHD, which could inspire further research to clarify the mechanisms.
By linking National Birth Registry with the National Health Insurance Research Database, Taiwan, we identified 2006-2015 birth cohort, which comprised 1,723,873 singleton live births, and conducted a nested case-control study. We included children with ADHD and compared them with non-ADHD controls matched with ADHD case on index date. Conditional logistic regression was utilized to calculate adjusted odds ratio (aOR) when investigating the association between parental diseases with risk of ADHD in their offspring.
The aOR (95% CI) of offspring\'s ADHD was 1.758 (1.458-2.119) with paternal OSA and 2.159 (1.442-3.233) with maternal OSA. The subgroup analysis revealed different effects of parental diseases among children\'s gender.
Our study demonstrates an association in parental OSA and offspring ADHD, which could inspire further research to clarify the mechanisms.
摘要：
阻塞性睡眠呼吸暂停(OSA),白天困倦，夜间缺氧，可导致全身炎症和氧化损伤。我们假设父母OSA，慢性全身性炎症和氧化应激，可能会导致儿童的神经发育障碍，比如ADHD。
通过将国家出生登记处与国家健康保险研究数据库联系起来，台湾,我们确定了2006-2015年出生队列，其中包括1,723,873例单胎活产，并进行了嵌套病例对照研究。我们纳入了患有ADHD的儿童，并在索引日期将其与与ADHD病例相匹配的非ADHD对照进行了比较。在调查父母疾病与后代ADHD风险之间的关联时，使用条件逻辑回归计算调整后的优势比（aOR）。
父系OSA后代ADHD的aOR（95％CI）为1.758（1.458-2.119），母系OSA为2.159（1.442-3.233）。亚组分析显示父母疾病对儿童性别的影响不同。
我们的研究表明父母OSA和后代ADHD之间存在关联，这可能会激发进一步的研究来澄清机制。
通过将国家出生登记处与国家健康保险研究数据库联系起来，
父系OSA后代ADHD的aOR（95％CI）为1.758（1.458-2.119），母系OSA为2.159（1.442-3.233）。
我们的研究表明父母OSA和后代ADHD之间存在关联，
