Abstract：
BACKGROUND: Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) is a mitochondrial disease. We report here the safe use of remimazolam in a pediatric MELAS patient.
METHODS: A 10-year-old girl (118 cm, 16 kg) was scheduled for an open gastrostomy to improve nutrition and epileptic seizure control. We induced and maintained general anesthesia with remimazolam, remifentanil, fentanyl, and rocuronium. We also performed a bilateral subcostal transversus abdominis plane block before the surgery. The surgery finished uneventfully. After we discontinued remimazolam administration, the patient woke up immediately but calmly without flumazenil. Epileptic seizures did not occur during intra- and early post-operative periods.
CONCLUSIONS: Remimazolam enabled us to provide a pediatric MELAS patient with general anesthesia without causing delayed emergence or epileptic seizures.
METHODS: A 10-year-old girl (118 cm, 16 kg) was scheduled for an open gastrostomy to improve nutrition and epileptic seizure control. We induced and maintained general anesthesia with remimazolam, remifentanil, fentanyl, and rocuronium. We also performed a bilateral subcostal transversus abdominis plane block before the surgery. The surgery finished uneventfully. After we discontinued remimazolam administration, the patient woke up immediately but calmly without flumazenil. Epileptic seizures did not occur during intra- and early post-operative periods.
CONCLUSIONS: Remimazolam enabled us to provide a pediatric MELAS patient with general anesthesia without causing delayed emergence or epileptic seizures.
摘要：
背景：线粒体脑肌病，乳酸性酸中毒,中风样发作（MELAS）是一种线粒体疾病。我们在此报告在小儿MELAS患者中安全使用雷米唑仑。
方法：一个10岁的女孩（118厘米，16公斤）计划进行开放式胃造口术，以改善营养和癫痫发作控制。我们用瑞马唑仑诱导并维持全身麻醉，瑞芬太尼,芬太尼,还有罗库溴铵.我们还在手术前进行了双侧肋下腹横肌平面阻滞。手术顺利完成。在我们停止服用雷米唑仑后,病人立刻醒来，但平静地没有氟马西尼。在手术中和术后早期未发生癫痫发作。
结论：雷马唑仑使我们能够为小儿MELAS患者提供全身麻醉，而不会引起出现延迟或癫痫发作。
方法：一个10岁的女孩（118厘米，16公斤）计划进行开放式胃造口术，以改善营养和癫痫发作控制。我们用瑞马唑仑诱导并维持全身麻醉，瑞芬太尼,芬太尼,还有罗库溴铵.我们还在手术前进行了双侧肋下腹横肌平面阻滞。手术顺利完成。在我们停止服用雷米唑仑后,病人立刻醒来，但平静地没有氟马西尼。在手术中和术后早期未发生癫痫发作。
结论：雷马唑仑使我们能够为小儿MELAS患者提供全身麻醉，而不会引起出现延迟或癫痫发作。
