Abstract：
Food allergy (FA) is a global health problem that affects a large population, and thus effective treatment is highly desirable. Oral immunotherapy (OIT) has been showing reasonable efficacy and favorable safety in most FA subjects. Dependable biomarkers are needed for treatment assessment and outcome prediction during OIT. Several immunological indicators have been used as biomarkers in OIT, such as skin prick tests, basophil and mast cell reactivity, T cell and B cell responses, allergen-specific antibody levels, and cytokines. Other novel indicators also could be potential biomarkers. In this review, we discuss and assess the application of various immunological indicators as biomarkers for OIT.
摘要：
食物过敏（FA）是一个影响大量人口的全球性健康问题，因此有效的治疗是非常理想的。口服免疫疗法（OIT）在大多数FA受试者中显示出合理的疗效和良好的安全性。OIT期间治疗评估和结果预测需要可靠的生物标志物。几种免疫学指标已被用作OIT的生物标志物，比如皮肤点刺试验,嗜碱性粒细胞和肥大细胞反应性，T细胞和B细胞反应，过敏原特异性抗体水平，和细胞因子。其他新型指标也可能是潜在的生物标志物。在这次审查中,我们讨论并评估了各种免疫学指标作为OIT生物标志物的应用。
