Abstract：
BACKGROUND: Fibrinogen to albumin ratio (FAR) is a newly investigated indicator for inflammation. The study aimed to explore the potential ability of FAR in assessing the severity of inflammation in spondyloarthritis.
METHODS: The clinical data of 196 spondyloarthritis (SpA) patients, 66 osteoarthritis (OA) patients, and 81 healthy controls (HC) were collected in this retrospective study. The SpA group included 69 psoriatic arthritis patients, 47 reactive arthritis patients and 80 ankylosing spondylitis patients. Chi-square test and Mann-Whitney U test, Spearman\'s correlation test, regression analysis, and ROC analyses were used for the analysis of FAR.
RESULTS: FAR level in group SpA was higher than in OA or HC. In the SpA group, the reactive arthritis group was characterized by the highest FAR level. After matching the erythrocyte sedimentation rate, a significant difference occurred between groups SpA and OA, but not in SpA subgroups. The FAR level was significantly related to erythrocyte sedimentation rate and C-reactive protein. After regression and receiver operating characteristics analysis, FAR was considered the most potential pointer to evaluate inflammation in SpA with the area under curve of 0.95. The recommended cut-off value of FAR was 9.44 for serious inflammation and 8.34 for mild conditions.
CONCLUSIONS: FAR is closely related to inflammatory biomarkers and can be a potential indicator in the assessment of inflammation in spondyloarthritis.
METHODS: The clinical data of 196 spondyloarthritis (SpA) patients, 66 osteoarthritis (OA) patients, and 81 healthy controls (HC) were collected in this retrospective study. The SpA group included 69 psoriatic arthritis patients, 47 reactive arthritis patients and 80 ankylosing spondylitis patients. Chi-square test and Mann-Whitney U test, Spearman\'s correlation test, regression analysis, and ROC analyses were used for the analysis of FAR.
RESULTS: FAR level in group SpA was higher than in OA or HC. In the SpA group, the reactive arthritis group was characterized by the highest FAR level. After matching the erythrocyte sedimentation rate, a significant difference occurred between groups SpA and OA, but not in SpA subgroups. The FAR level was significantly related to erythrocyte sedimentation rate and C-reactive protein. After regression and receiver operating characteristics analysis, FAR was considered the most potential pointer to evaluate inflammation in SpA with the area under curve of 0.95. The recommended cut-off value of FAR was 9.44 for serious inflammation and 8.34 for mild conditions.
CONCLUSIONS: FAR is closely related to inflammatory biomarkers and can be a potential indicator in the assessment of inflammation in spondyloarthritis.
摘要：
背景：纤维蛋白原与白蛋白之比（FAR）是新研究的炎症指标。该研究旨在探讨FAR评估脊柱关节炎炎症严重程度的潜在能力。
方法：分析196例脊柱关节炎(SpA)患者的临床资料,66名骨关节炎（OA）患者，在这项回顾性研究中收集了81名健康对照(HC)。SpA组包括69例银屑病关节炎患者，反应性关节炎患者47例，强直性脊柱炎患者80例。卡方检验和曼-惠特尼U检验，斯皮尔曼相关性检验，回归分析，和ROC分析用于FAR分析。
结果：SpA组FAR水平高于OA或HC组。在SpA小组中,反应性关节炎组的特点是FAR水平最高。在匹配红细胞沉降率之后,SpA和OA组之间存在显着差异，但不在SpA子组中。FAR水平与红细胞沉降率和C反应蛋白显著相关。经过回归和接收机工作特性分析，FAR被认为是评估SpA炎症的最潜在指标，曲线下面积为0.95。对于严重炎症，FAR的推荐临界值为9.44，对于轻度炎症，推荐临界值为8.34。
结论：FAR与炎症标志物密切相关，可作为脊柱关节炎炎症评估的潜在指标。
方法：分析196例脊柱关节炎(SpA)患者的临床资料,66名骨关节炎（OA）患者，在这项回顾性研究中收集了81名健康对照(HC)。SpA组包括69例银屑病关节炎患者，反应性关节炎患者47例，强直性脊柱炎患者80例。卡方检验和曼-惠特尼U检验，斯皮尔曼相关性检验，回归分析，和ROC分析用于FAR分析。
结果：SpA组FAR水平高于OA或HC组。在SpA小组中,反应性关节炎组的特点是FAR水平最高。在匹配红细胞沉降率之后,SpA和OA组之间存在显着差异，但不在SpA子组中。FAR水平与红细胞沉降率和C反应蛋白显著相关。经过回归和接收机工作特性分析，FAR被认为是评估SpA炎症的最潜在指标，曲线下面积为0.95。对于严重炎症，FAR的推荐临界值为9.44，对于轻度炎症，推荐临界值为8.34。
结论：FAR与炎症标志物密切相关，可作为脊柱关节炎炎症评估的潜在指标。
