Abstract：
OBJECTIVE: The aim of this article is to report a case of iatrogenic Cushing\'s disease associated with a delayed inflammatory response due to a facial dermal filler procedure.
METHODS: A case report according to CARE guidelines was performed. A delayed inflammatory reaction due to dermal filler injection resulted in iatrogenic Cushing\'s disease in a patient with no comorbidities or allergies.
RESULTS: Prolonged use of glucocorticoids can cause adverse effects, such as iatrogenic Cushing\'s disease. Dermal fillers have a very low incidence of complications, but these need to be discussed with patients. Drugs used to treat delayed inflammatory reaction include antibiotics, antihistamines, steroids, and intralesional hyaluronidase. Reversal of dermal fillers should be explained to the patient and included in the written consent.
CONCLUSIONS: Due to patient non-compliance and possible adverse effects of steroid medications, physicians should consider limiting their prescriptions of steroid medications to no more than 2 weeks and require frequent follow-up to discuss hyaluronidase if the condition returns off of steroid medication. In addition, it may be advisable to only treat with one filler brand, especially in the same session as this may be a risk factor.
METHODS: A case report according to CARE guidelines was performed. A delayed inflammatory reaction due to dermal filler injection resulted in iatrogenic Cushing\'s disease in a patient with no comorbidities or allergies.
RESULTS: Prolonged use of glucocorticoids can cause adverse effects, such as iatrogenic Cushing\'s disease. Dermal fillers have a very low incidence of complications, but these need to be discussed with patients. Drugs used to treat delayed inflammatory reaction include antibiotics, antihistamines, steroids, and intralesional hyaluronidase. Reversal of dermal fillers should be explained to the patient and included in the written consent.
CONCLUSIONS: Due to patient non-compliance and possible adverse effects of steroid medications, physicians should consider limiting their prescriptions of steroid medications to no more than 2 weeks and require frequent follow-up to discuss hyaluronidase if the condition returns off of steroid medication. In addition, it may be advisable to only treat with one filler brand, especially in the same session as this may be a risk factor.
摘要：
目的：本文的目的是报告一例医源性库欣病与面部真皮填充手术引起的延迟炎症反应相关。
方法：根据CARE指南进行病例报告。由于皮肤填充剂注射引起的延迟炎症反应导致患者发生医源性库欣病，没有合并症或过敏。
结果：长时间使用糖皮质激素会引起不良反应，如医源性库欣病。真皮填充剂的并发症发生率非常低，但是这些需要和病人讨论。用于治疗迟发性炎症反应的药物包括抗生素，抗组胺药,类固醇,和损伤内透明质酸酶。应向患者解释真皮填充剂的逆转，并包括在书面同意书中。
结论：由于患者的不依从性和类固醇药物可能的不良反应，医师应考虑将他们的类固醇药物处方限制在不超过2周,并且如果病情从类固醇药物治疗中恢复,则需要频繁随访以讨论透明质酸酶.此外,最好只使用一种填料品牌，特别是在同一次会议中，这可能是一个风险因素。
方法：根据CARE指南进行病例报告。由于皮肤填充剂注射引起的延迟炎症反应导致患者发生医源性库欣病，没有合并症或过敏。
结果：长时间使用糖皮质激素会引起不良反应，如医源性库欣病。真皮填充剂的并发症发生率非常低，但是这些需要和病人讨论。用于治疗迟发性炎症反应的药物包括抗生素，抗组胺药,类固醇,和损伤内透明质酸酶。应向患者解释真皮填充剂的逆转，并包括在书面同意书中。
结论：由于患者的不依从性和类固醇药物可能的不良反应，医师应考虑将他们的类固醇药物处方限制在不超过2周,并且如果病情从类固醇药物治疗中恢复,则需要频繁随访以讨论透明质酸酶.此外,最好只使用一种填料品牌，特别是在同一次会议中，这可能是一个风险因素。
