PDF(Pubmed)
Abstract：
UNASSIGNED: To advocate a single stage reconstruction in cases of maxillectomy and midfacial defects operated for covid associated mucormycosis to enable a favorable overall outcome within a shorter duration in terms of survival, quality of life, speech, deglutition and aesthetics.
UNASSIGNED: In our series of six patients with signs and symptoms suggestive of covid associated mucormycosis with diabetes as a predisposing factor had undergone Contrast enhanced CT and MRI with biopsy confirming the diagnosis, were then subsequently posted for resection and reconstruction depending upon extent of disease and defect left behind. Out of six, three were revision cases and the other three were primary cases. All had undergone single stage reconstruction using free flap (5/6) and pedicle (1/6) after intra-operative margins and distal most part of recipient vessels was found negative for mucormycosis on histopathology. Post-operative Liposomal Amphotericin B with Oral Posaconazole along with antibiotics and supportive treatment were given and were then followed up.
UNASSIGNED: All the cases have complete flap survival after a mean follow-up of 90 days with no recurrence of mucormycosis. We had a survival rate of 100% with patients having good quality of life, speech, deglutition and acceptable aesthetical outcome.
UNASSIGNED: Stepping up on the reconstruction ladder to provide a single stage management in patients of covid associated mucormycosis by adequate surgical debridement, intraoperative negative margins on histopathology and subsequent reconstruction using autologous flaps is the need of the hour to provide within a shorter duration, favourable overall outcome in terms of survival, quality of life, speech, deglutition and aesthetics.
UNASSIGNED: The online version contains supplementary material available at 10.1007/s12070-022-03121-1.
UNASSIGNED: In our series of six patients with signs and symptoms suggestive of covid associated mucormycosis with diabetes as a predisposing factor had undergone Contrast enhanced CT and MRI with biopsy confirming the diagnosis, were then subsequently posted for resection and reconstruction depending upon extent of disease and defect left behind. Out of six, three were revision cases and the other three were primary cases. All had undergone single stage reconstruction using free flap (5/6) and pedicle (1/6) after intra-operative margins and distal most part of recipient vessels was found negative for mucormycosis on histopathology. Post-operative Liposomal Amphotericin B with Oral Posaconazole along with antibiotics and supportive treatment were given and were then followed up.
UNASSIGNED: All the cases have complete flap survival after a mean follow-up of 90 days with no recurrence of mucormycosis. We had a survival rate of 100% with patients having good quality of life, speech, deglutition and acceptable aesthetical outcome.
UNASSIGNED: Stepping up on the reconstruction ladder to provide a single stage management in patients of covid associated mucormycosis by adequate surgical debridement, intraoperative negative margins on histopathology and subsequent reconstruction using autologous flaps is the need of the hour to provide within a shorter duration, favourable overall outcome in terms of survival, quality of life, speech, deglutition and aesthetics.
UNASSIGNED: The online version contains supplementary material available at 10.1007/s12070-022-03121-1.
摘要：
UNASSIGNED：提倡在上颌骨切除术和中面部缺损的病例中进行单阶段重建，以在较短的生存期内获得良好的总体结果，生活质量,演讲,吞咽和美学。
UNASSIGNED：在我们的6例患者中，这些患者的体征和症状提示与糖尿病相关的毛霉菌病是一个易感因素，他们接受了CT和MRI的对比增强和活检证实了诊断。然后根据留下的疾病和缺陷的程度进行切除和重建。六个人中,三例为修正病例,其余三例为主要病例.在术中边缘和组织病理学上发现受体血管远端大部分均未见毛霉菌病后，所有患者均使用游离皮瓣（5/6）和椎弓根（1/6）进行了单阶段重建。术后给予两性霉素B脂质体口服泊沙康唑，并给予抗生素和支持治疗，然后进行随访。
未经证实：平均随访90天后，所有病例均有完整的皮瓣成活，无毛霉菌病复发。我们的生存率为100％，患者的生活质量良好，演讲,吞咽和可接受的美学结果。
UNASSIGNED：加强重建阶梯，通过适当的手术清创术为covid相关性毛霉菌病患者提供单阶段管理，术中组织病理学阴性切缘和随后使用自体皮瓣重建需要在较短的时间内提供小时，就生存率而言，有利的总体结果，生活质量,演讲,吞咽和美学。
UNASSIGNED：在线版本包含补充材料，可在10.1007/s12070-022-03121-1获得。
UNASSIGNED：在我们的6例患者中，这些患者的体征和症状提示与糖尿病相关的毛霉菌病是一个易感因素，他们接受了CT和MRI的对比增强和活检证实了诊断。然后根据留下的疾病和缺陷的程度进行切除和重建。六个人中,三例为修正病例,其余三例为主要病例.在术中边缘和组织病理学上发现受体血管远端大部分均未见毛霉菌病后，所有患者均使用游离皮瓣（5/6）和椎弓根（1/6）进行了单阶段重建。术后给予两性霉素B脂质体口服泊沙康唑，并给予抗生素和支持治疗，然后进行随访。
未经证实：平均随访90天后，所有病例均有完整的皮瓣成活，无毛霉菌病复发。我们的生存率为100％，患者的生活质量良好，演讲,吞咽和可接受的美学结果。
UNASSIGNED：加强重建阶梯，通过适当的手术清创术为covid相关性毛霉菌病患者提供单阶段管理，术中组织病理学阴性切缘和随后使用自体皮瓣重建需要在较短的时间内提供小时，就生存率而言，有利的总体结果，生活质量,演讲,吞咽和美学。
UNASSIGNED：在线版本包含补充材料，可在10.1007/s12070-022-03121-1获得。
