PDF(Pubmed)
Abstract：
UNASSIGNED: The relationship between abnormal cortical plasticity and parkinsonian symptoms remains unclear in Parkinson\'s disease (PD).
UNASSIGNED: We studied the relationship between their symptoms and degree of Long-term potentiation (LTP)-like effects induced by quadripulse magnetic stimulation (QPS) over the primary motor cortex, which has a small inter-individual variability in humans.
UNASSIGNED: Participants were 16 PD patients (drug-naïve or treated with L-DOPA monotherapy) and 13 healthy controls (HC). LTP-like effects by QPS were compared between three conditions (HC､PD with or without L-DOPA). In PD, correlation analyses were performed between clinical scores (MDS-UPDRS, MMSE and MoCA-J) and the degree of LTP-like effects induced by QPS.
UNASSIGNED: In PD, QPS-induced LTP-like effect was reduced and restored by L-DOPA. The degree of the LTP was negatively correlated with MDS-UPDRS Part I and III scores, but not with MMSE and MoCA-J. In the sub-scores, upper limb bradykinesia and rigidity showed a negative correlation with the LTP-like effect whereas the tremor had no correlation.
UNASSIGNED: Our results suggest that motor cortical plasticity relate with mechanisms underlying bradykinesia and rigidity in the upper limb muscles. LTP induced by QPS may be used as an objective marker of parkinsonian symptoms.
UNASSIGNED: We studied the relationship between their symptoms and degree of Long-term potentiation (LTP)-like effects induced by quadripulse magnetic stimulation (QPS) over the primary motor cortex, which has a small inter-individual variability in humans.
UNASSIGNED: Participants were 16 PD patients (drug-naïve or treated with L-DOPA monotherapy) and 13 healthy controls (HC). LTP-like effects by QPS were compared between three conditions (HC､PD with or without L-DOPA). In PD, correlation analyses were performed between clinical scores (MDS-UPDRS, MMSE and MoCA-J) and the degree of LTP-like effects induced by QPS.
UNASSIGNED: In PD, QPS-induced LTP-like effect was reduced and restored by L-DOPA. The degree of the LTP was negatively correlated with MDS-UPDRS Part I and III scores, but not with MMSE and MoCA-J. In the sub-scores, upper limb bradykinesia and rigidity showed a negative correlation with the LTP-like effect whereas the tremor had no correlation.
UNASSIGNED: Our results suggest that motor cortical plasticity relate with mechanisms underlying bradykinesia and rigidity in the upper limb muscles. LTP induced by QPS may be used as an objective marker of parkinsonian symptoms.
摘要：
UNASSIGNED：在帕金森病（PD）中，皮质可塑性异常与帕金森病症状之间的关系尚不清楚。
UNASSIGNED：我们研究了它们的症状与初级运动皮质上的四脉冲磁刺激（QPS）引起的长期增强（LTP）样效应之间的关系，在人类中具有小的个体间变异性。
未经证实：参与者为16名PD患者（未接受药物治疗或接受L-DOPA单药治疗）和13名健康对照（HC）。比较了三种条件（有或没有L-DOPA的HC和PD）之间QPS的LTP样效应。在警察局，在临床评分(MDS-UPDRS，MMSE和MoCA-J）以及QPS诱导的LTP样效应程度。
未经批准：在PD中，L-DOPA降低并恢复了QPS诱导的LTP样效应。LTP的程度与MDS-UPDRS第一部分和第三部分得分呈负相关，但不是MMSE和MoCA-J在子分数中，上肢运动迟缓和僵硬与LTP样效应呈负相关，而震颤则无相关性。
UNASSIGNED：我们的结果表明，运动皮质可塑性与上肢肌肉运动迟缓和僵硬的潜在机制有关。QPS诱导的LTP可作为帕金森病症状的客观标志物。
UNASSIGNED：我们研究了它们的症状与初级运动皮质上的四脉冲磁刺激（QPS）引起的长期增强（LTP）样效应之间的关系，在人类中具有小的个体间变异性。
未经证实：参与者为16名PD患者（未接受药物治疗或接受L-DOPA单药治疗）和13名健康对照（HC）。比较了三种条件（有或没有L-DOPA的HC和PD）之间QPS的LTP样效应。在警察局，在临床评分(MDS-UPDRS，MMSE和MoCA-J）以及QPS诱导的LTP样效应程度。
未经批准：在PD中，L-DOPA降低并恢复了QPS诱导的LTP样效应。LTP的程度与MDS-UPDRS第一部分和第三部分得分呈负相关，但不是MMSE和MoCA-J在子分数中，上肢运动迟缓和僵硬与LTP样效应呈负相关，而震颤则无相关性。
UNASSIGNED：我们的结果表明，运动皮质可塑性与上肢肌肉运动迟缓和僵硬的潜在机制有关。QPS诱导的LTP可作为帕金森病症状的客观标志物。
