PDF(Pubmed)
Abstract：
In this paper, a reduced globus pallidus internal (GPI)-corticothalamic (GCT) model is developed, and a tri-phase delay stimulation (TPDS) with sequentially applying three pulses on the GPI representing the inputs from the striatal D 1 neurons, subthalamic nucleus (STN), and globus pallidus external (GPE), respectively, is proposed. The GPI is evidenced to control absence seizures characterized by 2 Hz-4 Hz spike and wave discharge (SWD). Hence, based on the basal ganglia-thalamocortical (BGCT) model, we firstly explore the triple effects of D l-GPI, GPE-GPI, and STN-GPI pathways on seizure patterns. Then, using the GCT model, we apply the TPDS on the GPI to potentially investigate the alternative and improved approach if these pathways to the GPI are blocked. The results show that the striatum D 1, GPE, and STN can indeed jointly and significantly affect seizure patterns. In particular, the TPDS can effectively reproduce the seizure pattern if the D 1-GPI, GPE-GPI, and STN-GPI pathways are cut off. In addition, the seizure abatement can be obtained by well tuning the TPDS stimulation parameters. This implies that the TPDS can play the surrogate role similar to the modulation of basal ganglia, which hopefully can be helpful for the development of the brain-computer interface in the clinical application of epilepsy.
摘要：
在本文中,开发了减少苍白球内部（GPI）-皮质丘脑（GCT）模型，和三相延迟刺激（TPDS），在GPI上顺序施加三个脉冲，代表纹状体D1神经元的输入，丘脑底核（STN），和外部苍白球（GPE），分别,是提议的。GPI被证明可以控制以2Hz-4Hz尖峰和波放电（SWD）为特征的失神癫痫发作。因此，基于基底神经节-丘脑皮质（BGCT）模型，我们首先探讨了Dl-GPI的三重效应，GPE-GPI,和STN-GPI途径对癫痫发作模式的影响。然后，使用GCT模型，我们将TPDS应用于GPI,以潜在研究如果这些通往GPI的途径被阻断的替代和改进方法.结果表明，纹状体D1、GPE、和STN确实可以共同且显着地影响癫痫发作模式。特别是,如果D1-GPI，TPDS可以有效地再现癫痫发作模式，GPE-GPI,STN-GPI通路被切断。此外,可以通过很好地调整TPDS刺激参数来获得癫痫发作的减少。这意味着TPDS可以发挥类似于基底神经节调制的替代作用，希望能对脑机接口在癫痫临床应用中的发展有所帮助。
