PDF(Pubmed)
Abstract：
UNASSIGNED: Amitriptyline is a tricyclic antidepressant drug accustomed to treat depressive disorders. It recorded many side effects on different tissues.
UNASSIGNED: To investigate reaction of Albino rats\' periodontium after oral administration of Amitriptyline histologically and radiographically.
UNASSIGNED: Fourteen adult male albino rats (150-200 g) were divided into two groups, control and experimental. Rats of experimental group received 10 mg⁄kg⁄day of Amitriptyline hydrochloride by oral gavage for four weeks. Mandibles were prepared for hematoxylin and eosin (H&E) and anti-osteopontin (Anti-OPN) immunohistochemistry staining. Bone mineral density was measured in mandibular alveolar bone. Statistical analysis for Anti-OPN and relative Hounsfield unit value (HU value) was performed using independent-samples t-test.
UNASSIGNED: Gingiva of experimental group showed epithelial degeneration with pyknotic nuclei and disintegration in lamina propria. Areas of separation in alveolar bone and degeneration of some regions in cementum were seen with apparent increase in periodontal ligament (PDL) thickness and its detachment from bone and cementum at some regions. Immunohistochemical examination of experimental group showed apparently increased immunopositivity in gingiva, cementocytes, osteocytes, cementum, bone matrices, fibroblasts and PDL fibers when compared to control group. Statistical analysis revealed insignificant difference of Anti-OPN area% in gingiva between both studied groups. While there was statistical significant increase of Anti-OPN area% in the other periodontium tissues and high statistical significant decrease of relative HU value in experimental group when compared to control.
UNASSIGNED: Amitriptyline has destructive effect on periodontal tissues and statistically increases the expression of Anti-OPN in all periodontal tissues except gingiva and decreases bone mineral density.
UNASSIGNED: To investigate reaction of Albino rats\' periodontium after oral administration of Amitriptyline histologically and radiographically.
UNASSIGNED: Fourteen adult male albino rats (150-200 g) were divided into two groups, control and experimental. Rats of experimental group received 10 mg⁄kg⁄day of Amitriptyline hydrochloride by oral gavage for four weeks. Mandibles were prepared for hematoxylin and eosin (H&E) and anti-osteopontin (Anti-OPN) immunohistochemistry staining. Bone mineral density was measured in mandibular alveolar bone. Statistical analysis for Anti-OPN and relative Hounsfield unit value (HU value) was performed using independent-samples t-test.
UNASSIGNED: Gingiva of experimental group showed epithelial degeneration with pyknotic nuclei and disintegration in lamina propria. Areas of separation in alveolar bone and degeneration of some regions in cementum were seen with apparent increase in periodontal ligament (PDL) thickness and its detachment from bone and cementum at some regions. Immunohistochemical examination of experimental group showed apparently increased immunopositivity in gingiva, cementocytes, osteocytes, cementum, bone matrices, fibroblasts and PDL fibers when compared to control group. Statistical analysis revealed insignificant difference of Anti-OPN area% in gingiva between both studied groups. While there was statistical significant increase of Anti-OPN area% in the other periodontium tissues and high statistical significant decrease of relative HU value in experimental group when compared to control.
UNASSIGNED: Amitriptyline has destructive effect on periodontal tissues and statistically increases the expression of Anti-OPN in all periodontal tissues except gingiva and decreases bone mineral density.
摘要：
未经批准：阿米替林是一种三环类抗抑郁药，用于治疗抑郁症。它记录了对不同组织的许多副作用。
UNASSIGNED：从组织学和影像学上研究口服阿米替林对白化病大鼠牙周组织的反应。
UNASSIGNED：将14只成年雄性白化病大鼠（150-200g）分为两组，控制和实验。实验组的大鼠通过口服管饲法接受10mg/kg/天的盐酸阿米替林，为期四周。准备下颌骨用于苏木精和伊红(H&E)和抗骨桥蛋白(抗OPN)免疫组织化学染色。在下颌牙槽骨中测量骨矿物质密度。使用独立样本t检验进行抗OPN和相对Hounsfield单位值(HU值)的统计分析。
未经证实：实验组牙龈表现为上皮变性，伴有固缩核和固有层崩解。可见牙槽骨的分离区域和牙骨质某些区域的变性，牙周膜（PDL）厚度明显增加，并且在某些区域与骨和牙骨质脱离。实验组的免疫组织化学检查显示牙龈中的免疫阳性明显增加。牙骨质细胞，骨细胞,牙骨质,骨基质,与对照组相比，成纤维细胞和PDL纤维。统计分析显示，两组之间牙龈中的抗OPN面积百分比差异无统计学意义。与对照组相比，实验组其他牙周组织中的抗OPN面积%有统计学上的显着增加，而相对HU值却有统计学上的显着降低。
UNASSIGNED：阿米替林对牙周组织具有破坏性作用，并在统计学上增加除牙龈外的所有牙周组织中Anti-OPN的表达，并降低骨矿物质密度。
UNASSIGNED：从组织学和影像学上研究口服阿米替林对白化病大鼠牙周组织的反应。
UNASSIGNED：将14只成年雄性白化病大鼠（150-200g）分为两组，控制和实验。实验组的大鼠通过口服管饲法接受10mg/kg/天的盐酸阿米替林，为期四周。准备下颌骨用于苏木精和伊红(H&E)和抗骨桥蛋白(抗OPN)免疫组织化学染色。在下颌牙槽骨中测量骨矿物质密度。使用独立样本t检验进行抗OPN和相对Hounsfield单位值(HU值)的统计分析。
未经证实：实验组牙龈表现为上皮变性，伴有固缩核和固有层崩解。可见牙槽骨的分离区域和牙骨质某些区域的变性，牙周膜（PDL）厚度明显增加，并且在某些区域与骨和牙骨质脱离。实验组的免疫组织化学检查显示牙龈中的免疫阳性明显增加。牙骨质细胞，骨细胞,牙骨质,骨基质,与对照组相比，成纤维细胞和PDL纤维。统计分析显示，两组之间牙龈中的抗OPN面积百分比差异无统计学意义。与对照组相比，实验组其他牙周组织中的抗OPN面积%有统计学上的显着增加，而相对HU值却有统计学上的显着降低。
UNASSIGNED：阿米替林对牙周组织具有破坏性作用，并在统计学上增加除牙龈外的所有牙周组织中Anti-OPN的表达，并降低骨矿物质密度。
