PDF(Pubmed)
Abstract：
For traditional artificial dermises, a waiting period of approximately three weeks is required after the first implantation before they are adequately vascularized. The objective of this retrospective case series was to investigate whether full-thickness skin defects, requiring surgical reconstruction, could be successfully treated by implantation of a basic fibroblast growth factor (bFGF)-impregnated artificial dermis and secondary skin grafting with a shorter waiting period. Between January 2019 and January 2021, 19 skin defects in 14 patients (7 male and 7 female) were treated with two-stage skin grafting using bFGF-impregnated collagen-gelatin sponge (CGS). All of them were included in this case series, and the waiting period for skin grafting, success rate of skin grafting, infection during the waiting period, and scar quality 6-12 months postoperatively were retrospectively investigated. As a result, all skin grafting surgeries were successfully performed with a waiting period of 13.3 ± 4.3 days. Infection during the waiting period was observed in three lesions (15.8%); however, all infections were controllable. Postoperative scar quality was acceptable (Vancouver Scar Scale score range, 1-8). In conclusion, compared to traditional artificial dermises, bFGF-impregnated CGSs have the potential to shorten the waiting period without decreasing the success rate of skin grafting. Further studies are required to confirm this finding.
摘要：
对于传统的人工验证，第一次植入后需要大约三周的等待期，然后才能充分血管化。这个回顾性病例系列的目的是调查全层皮肤缺损，需要手术重建,可以通过植入碱性成纤维细胞生长因子（bFGF）浸渍的人工真皮并在较短的等待时间内进行二次皮肤移植来成功治疗。在2019年1月至2021年1月之间，使用bFGF浸渍的胶原蛋白-明胶海绵（CGS）进行了两阶段皮肤移植，治疗了14例患者（7例男性和7例女性）的19例皮肤缺损。所有这些都包含在这个案例系列中，还有植皮的等待期,植皮成功率,在等待期间感染，术后6～12个月对瘢痕质量进行回顾性调查。因此,所有植皮手术均成功进行，等待期为13.3±4.3天。在等待期间，在三个病变中观察到感染（15.8％）；但是，所有感染都是可控的.术后瘢痕质量可接受（温哥华瘢痕评分范围，1-8).总之,与传统的人工验证相比，bFGF浸渍的CGSs有可能缩短等待期，而不会降低皮肤移植的成功率。需要进一步的研究来证实这一发现。
