UNASSIGNED: Patients with PSC and concurrent NRH on liver biopsy were identified from the digital pathology database covering the period 2003-2019. Evaluation of liver biopsy and the original diagnoses were confirmed on review based on standard histological features diagnostic for NRH and OPV. Clinical and laboratory data were obtained from electronic medical records.
UNASSIGNED: Thirty-one patients (21 male, 10 female; median age at biopsy 40.1 years) were included in the study. Twelve (38.7%) patients had OPV in addition to NRH on the liver biopsy. Nineteen (61.2%) patients had IBD including 11 with Crohn\'s disease (CD), 7 with ulcerative colitis (UC), and 1 with indeterminate colitis. Thirteen (41.9%) patients had evidence of portal hypertension, 10 (32.2%) with esophageal varices, 4 (12.9%) with history of variceal bleeding, 6 (19.3%) with ascites, and 14 (12.9%) with splenomegaly. Eleven (35.4%) patients had a cirrhotic-appearing liver on imaging. Twelve (38.7%) patients had a history of prior or current thiopurine use.
UNASSIGNED: The current study suggests that NRH with or without OPV independently occurs in patients having PSC and may lead to NCPH, even in the absence of concurrent IBD and/or thiopurine therapy.
UNASSIGNED:从涵盖2003-2019年期间的数字病理学数据库中确定了PSC和同时进行肝活检的NRH患者。肝活检的评估和原始诊断在基于NRH和OPV诊断的标准组织学特征的审查中得到证实。从电子病历中获得临床和实验室数据。
未经证实:31名患者(21名男性,10名女性;活检时的中位年龄40.1岁)被纳入研究。12例(38.7%)患者在肝活检中除NRH外还进行了OPV。19例(61.2%)患者患有IBD,其中11例患有克罗恩病(CD),7与溃疡性结肠炎(UC),1例不确定结肠炎。13例(41.9%)患者有门静脉高压的证据,10例(32.2%)食管静脉曲张,4例(12.9%)有静脉曲张破裂出血史,6(19.3%)伴腹水,脾肿大14例(12.9%)。11例(35.4%)患者在影像学上出现肝硬化。12例(38.7%)患者有既往或目前使用硫嘌呤的病史。
未经证实:目前的研究表明,有或没有OPV的NRH独立发生在PSC患者中,并可能导致NCPH,即使在没有并发IBD和/或噻嘌呤治疗的情况下。