Abstract：
The investigation of tumor microenvironment (TME) is essential to better characterize the complex cellular crosstalk and to identify important immunological phenotypes and biomarkers. The niche is a crucial contributor to neoplasm initiation, maintenance and progression. Therefore, a deeper analysis of tumor surroundings could improve cancer diagnosis, prognosis and assertive treatment. Thus, the WNT family exerts a critical action in tumorigenesis of different types of neoplasms due to dysregulations in the TME. WNT5A, an evolutionary WNT member, is involved in several cellular and physiopathological processes, in addition to tissue homeostasis. The WNT5A protein exerts paradoxical effects while acting as both an oncogene or tumor suppressor by regulating several non-canonical signaling pathways, and consequently interfering in cell growth, cytoskeletal remodeling, migration and invasiveness. This review focuses on a thorough characterization of the role of WNT5A in neoplastic transformation and progression, which may help to understand the prognostic potentiality of WNT5A and its features as a therapeutic target in several cancers. Additionally, we herein summarized novel findings on the mechanisms by which WNT5A might favor tumorigenesis or suppression of cancer progression and discussed the recently developed treatment strategies using WNT5A as a protagonist.
摘要：
肿瘤微环境（TME）的研究对于更好地表征复杂的细胞串扰以及识别重要的免疫表型和生物标志物至关重要。生态位是肿瘤发生的关键因素，维护和进展。因此,对肿瘤环境进行更深入的分析可以改善癌症的诊断，预后和积极的治疗。因此，由于TME的失调，WNT家族在不同类型肿瘤的肿瘤发生中起关键作用。WNT5A,进化的WNT成员，参与了几个细胞和病理生理过程，除了组织稳态。WNT5A蛋白发挥矛盾作用，同时通过调节几种非经典信号通路作为癌基因或肿瘤抑制因子，从而干扰细胞生长，细胞骨架重塑，移民和入侵。这篇综述的重点是全面描述WNT5A在肿瘤转化和进展中的作用。这可能有助于了解WNT5A的预后潜力及其作为几种癌症治疗靶标的特征。此外,我们在此总结了关于WNT5A可能促进肿瘤发生或抑制癌症进展的机制的新发现,并讨论了最近开发的以WNT5A为主角的治疗策略.
