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Abstract：
In this study, we aimed to investigate whether fibrinogen degradation products(FDP)and D-dimer could be used as serological indicators of rheumatoid arthritis(RA) activity, such as erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and platelets (PLT). A total of 112 consecutive patients with RA between July 2018 and July 2020 were divided into moderate and high disease activity groups (disease activity score 28(DAS28) > 3.2, n = 60) and low disease activity and remission groups (DAS28≤3.2, n = 52). A total of 50 healthy volunteers were included in the control group, and FDP and D-dimer levels were compared across the three groups. The correlations of FDP and D-dimer levels with ESR, CRP, PLT, and DAS28 were analyzed. Analyses of the receiver operating characteristic(ROC) curves and area under the ROC curve (AUC) of FDP, D-dimer, ESR, CRP, and PLT levels were performed. FDP and D-dimer levels were significantly higher in the high-activity compared to the low-activity and remission (P < .001), and the control (P < .001). No significant differences in FDP and D-dimer were observed between the low-activity and remission and the control (P > .05). FDP and D-dimer levels were positively correlated with ESR, CRP, PLT, and DAS28 (all P < .001). The ROC curves showed that the FDP and D-dimer levels could be used to evaluate the RA activity (all P < .001). The AUC of FDP was significantly larger than that of PLT (P = .047). FDP and D-dimer can be used as supplementary serological indicators to assess RA activity, in addition to ESR, CRP, and PLT.
摘要：
在这项研究中,我们旨在研究纤维蛋白原降解产物（FDP）和D-二聚体是否可以用作类风湿关节炎（RA）活性的血清学指标，如红细胞沉降率(ESR)，C反应蛋白(CRP),和血小板（PLT）。2018年7月至2020年7月，共112例RA连续患者分为中度和高度疾病活动度组(疾病活动度评分28(DAS28)>3.2，n=60)和低疾病活动度和缓解组(DAS28≤3.2，n=52)。将50名健康志愿者纳入对照组,比较三组的FDP和D-二聚体水平。FDP和D-二聚体水平与血沉的相关性,CRP,PLT,并对DAS28进行了分析。FDP的受试者工作特征(ROC)曲线和ROC曲线下面积(AUC)分析,D-二聚体,ESR,CRP,和PLT水平进行。FDP和D-二聚体水平在高活性组明显高于低活性组和缓解组(P<.001),和对照(P<.001)。FDP和D-二聚体在低活性和缓解期与对照组之间无显著差异(P>.05)。FDP和D-二聚体水平与ESR呈正相关,CRP,PLT,和DAS28（所有P<.001）。ROC曲线显示FDP和D-二聚体水平可用于评估RA活性（均P<.001）。FDP的AUC显著大于PLT(P=.047)。FDP和D-二聚体可作为评估RA活性的补充血清学指标。除了ESR,CRP,和PLT。
