Abstract：
OBJECTIVE: This study investigated the frequency of cancer-associated vasculitis, the types of associated cancers and vasculitides, and the temporal relationship in Korean patients who were diagnosed with both cancers and vasculitides.
METHODS: This study performed a digital search of the clinical data repository using selected diagnostic terms of vasculitides among patients diagnosed with cancers from May 2001 to May 2021. The time gap between the time of diagnosis of \'cancers\' and that of \'vasculitides\' was limited to 3 years. The types of cancers and vasculitides were reviewed.
RESULTS: The mean age of 73 patients with both cancers and vasculitides with a time gap of fewer than 3 years was 53.0 years and 42.5% were men. Of the 215,897 patients with cancers, 73 patients were also diagnosed with vasculitides (0.034%). The most common type of cancer was thyroid cancer (28.8%), followed by lymphoma (13.7%), whereas the most frequent type of vasculitis associated with cancer was Behcet disease (52.1%), followed by granulomatosis with polyangiitis (12.3%). The median time gap between cancer and vasculitis was - 17.0 days. Among vasculitides, Behcet disease was closely associated with various cancers compared to other types. Twenty-one patients exhibited both cancers and vasculitides between 0 and 90 days after the diagnosis of the corresponding cancer.
CONCLUSIONS: The frequency of cancer-associated vasculitis was 0.034% in Korean patients. The types of cancers and vasculitides in cancer-associated vasculitis and the distributions of sex and age may be dependent on ethnic and geographic differences. Key Points • The frequency of cancer-associated vasculitis was 0.034% in Korean patients. • The most common cancer and vasculitis in cancer-associated vasculitis were thyroid cancer and Behcet disease. • The types of cancers and vasculitides in cancer-associated vasculitis seemed to be dependent on ethnic and geographic differences.
METHODS: This study performed a digital search of the clinical data repository using selected diagnostic terms of vasculitides among patients diagnosed with cancers from May 2001 to May 2021. The time gap between the time of diagnosis of \'cancers\' and that of \'vasculitides\' was limited to 3 years. The types of cancers and vasculitides were reviewed.
RESULTS: The mean age of 73 patients with both cancers and vasculitides with a time gap of fewer than 3 years was 53.0 years and 42.5% were men. Of the 215,897 patients with cancers, 73 patients were also diagnosed with vasculitides (0.034%). The most common type of cancer was thyroid cancer (28.8%), followed by lymphoma (13.7%), whereas the most frequent type of vasculitis associated with cancer was Behcet disease (52.1%), followed by granulomatosis with polyangiitis (12.3%). The median time gap between cancer and vasculitis was - 17.0 days. Among vasculitides, Behcet disease was closely associated with various cancers compared to other types. Twenty-one patients exhibited both cancers and vasculitides between 0 and 90 days after the diagnosis of the corresponding cancer.
CONCLUSIONS: The frequency of cancer-associated vasculitis was 0.034% in Korean patients. The types of cancers and vasculitides in cancer-associated vasculitis and the distributions of sex and age may be dependent on ethnic and geographic differences. Key Points • The frequency of cancer-associated vasculitis was 0.034% in Korean patients. • The most common cancer and vasculitis in cancer-associated vasculitis were thyroid cancer and Behcet disease. • The types of cancers and vasculitides in cancer-associated vasculitis seemed to be dependent on ethnic and geographic differences.
摘要：
目的：本研究调查了癌症相关性血管炎的发生频率，相关癌症和血管炎的类型，以及被诊断患有癌症和血管炎的韩国患者的时间关系。
方法：本研究在2001年5月至2021年5月诊断为癌症的患者中，使用选定的血管炎诊断术语对临床数据存储库进行了数字搜索。诊断“癌症”和“血管炎”之间的时间间隔限制为3年。综述了癌症和血管炎的类型。
结果：73例同时患有癌症和血管炎且时间间隔小于3年的患者的平均年龄为53.0岁，其中42.5%为男性。在215,897名癌症患者中，73例患者也被诊断为血管炎（0.034％）。最常见的癌症类型是甲状腺癌（28.8%），其次是淋巴瘤(13.7%),而与癌症相关的血管炎最常见的类型是Behcet病（52.1％），其次是肉芽肿性多血管炎(12.3%)。癌症和血管炎之间的中位时间间隔为-17.0天。在血管炎中，与其他类型相比，白塞病与各种癌症密切相关。21名患者在诊断出相应癌症后0至90天之间同时表现出癌症和血管炎。
结论：韩国患者癌症相关性血管炎的发生率为0.034%。癌症相关血管炎中的癌症和血管炎的类型以及性别和年龄的分布可能取决于种族和地理差异。要点•韩国患者癌症相关性血管炎的发生率为0.034%。•癌症相关性血管炎中最常见的癌症和血管炎是甲状腺癌和白塞病。•癌症相关血管炎中的癌症和血管炎类型似乎取决于种族和地理差异。
方法：本研究在2001年5月至2021年5月诊断为癌症的患者中，使用选定的血管炎诊断术语对临床数据存储库进行了数字搜索。诊断“癌症”和“血管炎”之间的时间间隔限制为3年。综述了癌症和血管炎的类型。
结果：73例同时患有癌症和血管炎且时间间隔小于3年的患者的平均年龄为53.0岁，其中42.5%为男性。在215,897名癌症患者中，73例患者也被诊断为血管炎（0.034％）。最常见的癌症类型是甲状腺癌（28.8%），其次是淋巴瘤(13.7%),而与癌症相关的血管炎最常见的类型是Behcet病（52.1％），其次是肉芽肿性多血管炎(12.3%)。癌症和血管炎之间的中位时间间隔为-17.0天。在血管炎中，与其他类型相比，白塞病与各种癌症密切相关。21名患者在诊断出相应癌症后0至90天之间同时表现出癌症和血管炎。
结论：韩国患者癌症相关性血管炎的发生率为0.034%。癌症相关血管炎中的癌症和血管炎的类型以及性别和年龄的分布可能取决于种族和地理差异。要点•韩国患者癌症相关性血管炎的发生率为0.034%。•癌症相关性血管炎中最常见的癌症和血管炎是甲状腺癌和白塞病。•癌症相关血管炎中的癌症和血管炎类型似乎取决于种族和地理差异。
