Abstract：
BACKGROUND: As previously reported, an increased repolarization temporal imbalance induces a higher risk of total/cardiovascular mortality.
OBJECTIVE: The aim of this study was to assess if the electrocardiographic short period markers of repolarization temporal dispersion could be predictive of the hospital stay length and mortality in patients with acutely decompensated chronic heart failure (CHF).
METHODS: Mean, standard deviation (SD), and normalized variance (VN) of QT (QT) and Tpeak-Tend (Te) were obtained on 5-min ECG recording in 139 patients hospitalized for acutely decompensated CHF, subgrouping the patients for hospital length of stay (LoS): less or equal 1 week (≤1 W) and those with more than 1 week (>1 W).
RESULTS: We observed an increase of short-period repolarization variables (TeSD and TeVN, p < .05), a decrease of blood pressure (p < .05), lower ejection fraction (p < .05), and higher plasma level of biomarkers (NT-proBNP, p < .001; Troponin, p < .05) in >1 W LoS subjects. 30-day deceased subjects reported significantly higher levels of QTSD (p < .05), Te mean (p < .001), TeSD (p < .05), QTVN (p < .05) in comparison to the survivors. Multivariable Cox regression analysis reported that TeVN was a risk factor for longer hospital stay (hazard ratio: 1.04, 95% confidence limit: 1.01-1.08, p < .05); whereas, a longer Te mean was associated with higher mortality risk (hazard ratio: 1.02, 95% confidence limit: 1.01-1.03, p < .05).
CONCLUSIONS: A longer hospital stay is considered a clinical surrogate of CHF severity, we confirmed this finding. Therefore, these electrical and simple parameters could be used as noninvasive, transmissible, inexpensive markers of CHF severity and mortality.
OBJECTIVE: The aim of this study was to assess if the electrocardiographic short period markers of repolarization temporal dispersion could be predictive of the hospital stay length and mortality in patients with acutely decompensated chronic heart failure (CHF).
METHODS: Mean, standard deviation (SD), and normalized variance (VN) of QT (QT) and Tpeak-Tend (Te) were obtained on 5-min ECG recording in 139 patients hospitalized for acutely decompensated CHF, subgrouping the patients for hospital length of stay (LoS): less or equal 1 week (≤1 W) and those with more than 1 week (>1 W).
RESULTS: We observed an increase of short-period repolarization variables (TeSD and TeVN, p < .05), a decrease of blood pressure (p < .05), lower ejection fraction (p < .05), and higher plasma level of biomarkers (NT-proBNP, p < .001; Troponin, p < .05) in >1 W LoS subjects. 30-day deceased subjects reported significantly higher levels of QTSD (p < .05), Te mean (p < .001), TeSD (p < .05), QTVN (p < .05) in comparison to the survivors. Multivariable Cox regression analysis reported that TeVN was a risk factor for longer hospital stay (hazard ratio: 1.04, 95% confidence limit: 1.01-1.08, p < .05); whereas, a longer Te mean was associated with higher mortality risk (hazard ratio: 1.02, 95% confidence limit: 1.01-1.03, p < .05).
CONCLUSIONS: A longer hospital stay is considered a clinical surrogate of CHF severity, we confirmed this finding. Therefore, these electrical and simple parameters could be used as noninvasive, transmissible, inexpensive markers of CHF severity and mortality.
摘要：
背景：如先前报道，复极时间失衡增加导致总死亡率/心血管死亡率的风险更高.
目的：本研究的目的是评估心电图短期复极时间离散度标志物是否可以预测急性失代偿性慢性心力衰竭（CHF）患者的住院时间和死亡率。
方法：平均值，标准偏差(SD)，在139例因严重失代偿CHF住院的患者中，通过5分钟的ECG记录获得了QT（QT）和Tpeak-Tend（Te）的归一化方差（VN），根据住院时间（LoS）对患者进行分组：小于或等于1周（≤1W）和大于1周（>1W）。
结果：我们观察到短周期复极化变量的增加（TeSD和TeVN，p<.05)，血压下降（p<0.05），降低射血分数（p<0.05），和更高的血浆生物标志物水平(NT-proBNP，p<.001；肌钙蛋白，p<0.05）>1WLoS科目。30天死亡的受试者报告QTSD水平显着升高（p<0.05），Te平均值(p<.001)，TeSD（p<0.05），与幸存者相比，QTVN(p<.05)。多变量Cox回归分析报告说，TeVN是住院时间较长的危险因素（风险比：1.04，95％置信限：1.01-1.08，p<0.05）；然而，较长的Te均值与较高的死亡风险相关(风险比:1.02,95%置信限:1.01-1.03,p<.05).
结论：长期住院被认为是CHF严重程度的临床替代因素，我们证实了这一发现。因此,这些电学和简单的参数可以用作非侵入性的，可传播的,CHF严重程度和死亡率的廉价标志物。
目的：本研究的目的是评估心电图短期复极时间离散度标志物是否可以预测急性失代偿性慢性心力衰竭（CHF）患者的住院时间和死亡率。
方法：平均值，标准偏差(SD)，在139例因严重失代偿CHF住院的患者中，通过5分钟的ECG记录获得了QT（QT）和Tpeak-Tend（Te）的归一化方差（VN），根据住院时间（LoS）对患者进行分组：小于或等于1周（≤1W）和大于1周（>1W）。
结果：我们观察到短周期复极化变量的增加（TeSD和TeVN，p<.05)，血压下降（p<0.05），降低射血分数（p<0.05），和更高的血浆生物标志物水平(NT-proBNP，p<.001；肌钙蛋白，p<0.05）>1WLoS科目。30天死亡的受试者报告QTSD水平显着升高（p<0.05），Te平均值(p<.001)，TeSD（p<0.05），与幸存者相比，QTVN(p<.05)。多变量Cox回归分析报告说，TeVN是住院时间较长的危险因素（风险比：1.04，95％置信限：1.01-1.08，p<0.05）；然而，较长的Te均值与较高的死亡风险相关(风险比:1.02,95%置信限:1.01-1.03,p<.05).
结论：长期住院被认为是CHF严重程度的临床替代因素，我们证实了这一发现。因此,这些电学和简单的参数可以用作非侵入性的，可传播的,CHF严重程度和死亡率的廉价标志物。
