UNASSIGNED: Retrospective analysis was performed on the EP/ELBW infants discharged from 26 tertiary neonatal intensive care units or died during hospitalization from 2008 to 2017, who were divided into HDP group and non-HDP group. The six covariates including sex, gestational age, birth weight, twin or multiple pregnancy, antenatal steroids administration, and conception method were matched through the PSM method at a ratio of 1:1. The survival rate at discharge and the major clinical complications were compared between the two groups.
UNASSIGNED: After matching the six covariates, compared with the non-HDP group, there was no significant difference in the survival rate at discharge (64 vs. 63.2%, p > 0.05), the incidence of bronchopulmonary dysplasia (BPD) or moderate to severe BPD in the HDP group (58.3 vs. 54.9%, p > 0.05; 5.2 vs. 6.2%, p > 0.05). The incidence of periventricular leukomalacia (PVL) in the HDP group was significantly increased (5.7 vs. 1.9%, p < 0.05).
UNASSIGNED: HDP increased the risk of PVL in EP/ELBW infants, but had no significant effect on the survival rate at discharge, or the occurrence of other complications.
UNASSIGNED:回顾性分析2008-2017年26例三级新生儿重症监护病房出院或住院期间死亡的EP/ELBW婴儿,分为HDP组和非HDP组。六个协变量包括性别,胎龄,出生体重,双胎或多胎妊娠,产前类固醇管理,和概念方法通过PSM方法以1:1的比例匹配。比较两组患者出院时的生存率及主要临床并发症。
未经评估:匹配六个协变量后,与非HDP组相比,出院时的生存率没有显着差异(64vs.63.2%,P>0.05),HDP组支气管肺发育不良(BPD)或中度至重度BPD的发生率(58.3vs.54.9%,p>0.05;5.2vs.6.2%,p>0.05)。HDP组脑室周围白质软化(PVL)的发生率显着增加(5.7vs.1.9%,p<0.05)。
未经证实:HDP增加EP/ELBW婴儿PVL的风险,但对出院时的存活率没有显著影响,或其他并发症的发生。