Abstract：
It is unclear if cutaneous microvascular dysfunction associated with diabetes and obesity can be ameliorated with exercise. We investigated the effect of 12-weeks of exercise training on cutaneous microvascular reactivity in the foot. Thirty-three inactive adults with type 2 diabetes and obesity (55% male, 56.1 ± 7.9 years, BMI: 35.8 ± 5, diabetes duration: 7.9 ± 6.3 years) were randomly allocated to 12-weeks of either (i) moderate-intensity continuous training [50−60% peak oxygen consumption (VO2peak), 30−45 min, 3 d/week], (ii) low-volume high-intensity interval training (90% VO2peak, 1−4 min, 3 d/week) or (iii) sham exercise placebo. Post-occlusive reactive hyperaemia at the hallux was determined by laser-Doppler fluxmetry. Though time to peak flux post-occlusion almost halved following moderate intensity exercise, no outcome measure reached statistical significance (p > 0.05). These secondary findings from a randomised controlled trial are the first data reporting the effect of exercise interventions on cutaneous microvascular reactivity in the foot in people with diabetes. A period of 12 weeks of moderate-intensity or low-volume high-intensity exercise may not be enough to elicit functional improvements in foot microvascular reactivity in adults with type 2 diabetes and obesity. Larger, sufficiently powered, prospective studies are necessary to determine if additional weight loss and/or higher exercise volume is required.
摘要：
目前尚不清楚与糖尿病和肥胖相关的皮肤微血管功能障碍是否可以通过运动得到改善。我们研究了12周运动训练对足部皮肤微血管反应性的影响。33名患有2型糖尿病和肥胖症的非活跃成年人（55%为男性，56.1±7.9年，BMI：35.8±5，糖尿病持续时间：7.9±6.3年）被随机分配到12周的（i）中等强度连续训练[50-60％峰值耗氧量（VO2peak），30-45分钟,3天/周]，(ii)小量高强度间歇训练(90%VO2peak，1-4分钟,3d/周）或（iii）假运动安慰剂。通过激光多普勒通量法确定hallux闭塞后反应性充血。尽管在中等强度运动后，阻塞后达到峰值通量的时间几乎减少了一半，结果测量无统计学意义(p>0.05)。来自随机对照试验的这些次要发现是首次报告运动干预对糖尿病患者足部皮肤微血管反应性的影响的数据。12周的中等强度或少量高强度运动可能不足以引起患有2型糖尿病和肥胖症的成年人足部微血管反应性的功能改善。较大,足够的动力，前瞻性研究是必要的，以确定是否需要额外的减肥和/或更高的运动量。
