Abstract：
PTPN2 (protein tyrosine phosphatase non-receptor 2), also called TCPTP (T cell protein tyrosine phosphatase), is a member of the PTP family signaling proteins. Phosphotyrosine-based signaling of this non-transmembrane protein is essential for regulating cell growth, development, differentiation, survival, and migration. In particular, PTPN2 received researchers\' attention when Manguso et al. identified PTPN2 as a cancer immunotherapy target using in vivo CRISPR library screening. In this review, we attempt to summarize the important functions of PTPN2 in terms of its structural and functional properties, inflammatory reactions, immunomodulatory properties, and tumor immunity. PTPN2 exerts synergistic anti-inflammatory effects in various inflammatory cells and regulates the developmental differentiation of immune cells. The diversity of PTPN2 effects in different types of tumors makes it a potential target for tumor immunotherapy.
摘要：
PTPN2（蛋白酪氨酸磷酸酶非受体2），也称为TCPTP（T细胞蛋白酪氨酸磷酸酶），是PTP家族信号蛋白的成员。这种非跨膜蛋白的基于磷酸酪氨酸的信号传导对于调节细胞生长至关重要，发展,分化,生存,和移民。特别是,PTPN2在Manguso等人的时候受到了研究人员的关注。使用体内CRISPR文库筛选将PTPN2鉴定为癌症免疫疗法靶标。在这次审查中,我们试图从结构和功能特性方面总结PTPN2的重要功能，炎症反应，免疫调节特性，和肿瘤免疫。PTPN2在各种炎症细胞中发挥协同抗炎作用，并调节免疫细胞的发育分化。PTPN2在不同类型肿瘤中作用的多样性使其成为肿瘤免疫治疗的潜在靶点。
