Abstract：
Osteoclastogenesis is an ongoing rigorous course that includes osteoclast precursors fusion and bone resorption executed by degradative enzymes. Osteoclastogenesis is controlled by endogenous signaling and/or regulators or affected by exogenous conditions and can also be controlled both internally and externally. More evidence indicates that autophagy, inflammation, and immunity are closely related to osteoclastogenesis and involve multiple intracellular organelles (e.g., lysosomes and autophagosomes) and certain inflammatory or immunological factors. Based on the literature on osteoclastogenesis induced by different regulatory aspects, emerging basic cross-studies have reported the emerging disquisitive orientation for osteoclast differentiation and function. In this review, we summarize the partial potential therapeutic targets for osteoclast differentiation and function, including the signaling pathways and various cellular processes.
摘要：
破骨细胞生成是一个持续的严格过程，包括破骨细胞前体融合和由降解酶执行的骨吸收。破骨细胞生成受内源性信号传导和/或调节剂控制或受外源性条件影响,并且还可以在内部和外部受到控制。更多的证据表明自噬,炎症,和免疫与破骨细胞生成密切相关，并涉及多个细胞内细胞器(例如，溶酶体和自噬体）和某些炎症或免疫因子。根据不同调控方面诱导的破骨细胞生成的文献，新兴的基础交叉研究报道了破骨细胞分化和功能的新兴研究方向。在这次审查中,我们总结了破骨细胞分化和功能的部分潜在治疗靶点，包括信号通路和各种细胞过程。
