PDF(Pubmed)
Abstract：
Ceramides are a class of sphingolipids which are implicated in skin disorders, obesity, and other metabolic diseases. As a class with pleiotropic effects, recent efforts have centred on discerning specific ceramide species and their effects on atopic dermatitis, obesity, type 2 diabetes, and cardiovascular diseases. This delineation has allowed the identification of disease biomarkers, with long acyl chain ceramides such as C16- and C18-ceramides linked to metabolic dysfunction and cardiac function decline, while ultra-long acyl chain ceramides (>25 carbon acyl chain) were reported to be essential for maintaining a functional skin barrier. Given the intricate link between free fatty acids with ceramides, especially the de novo synthetic pathway, intracellular lipid droplet formation is increasingly viewed as an important mechanism for preventing accumulation of toxic ceramide species. Here, we review recent reports of various ceramide species involved in skin abnormalities and metabolic diseases, and we propose that promotion of lipid droplet biogenesis can be seen as a potential protective mechanism against deleterious ceramides.
摘要：
神经酰胺是一类与皮肤病有关的鞘脂，肥胖，和其他代谢疾病。作为一个具有多效性的类，最近的努力集中在辨别特定的神经酰胺种类及其对特应性皮炎的影响，肥胖，2型糖尿病,和心血管疾病。这种划分允许识别疾病生物标志物，与C16-和C18-神经酰胺等长酰基链神经酰胺与代谢功能障碍和心脏功能下降有关，而据报道，超长酰基链神经酰胺（＆gt;25碳酰基链）对于维持功能性皮肤屏障至关重要。鉴于游离脂肪酸与神经酰胺之间的复杂联系，尤其是从头合成途径，细胞内脂滴的形成越来越被视为防止有毒神经酰胺物质积累的重要机制。这里,我们回顾了最近关于各种神经酰胺与皮肤异常和代谢性疾病有关的报道，我们认为，促进脂滴生物合成可以被视为一种潜在的保护机制，对抗有害的神经酰胺。
