PDF(Pubmed)
Abstract：
An approximately 12-year-old, 31 kg, male neutered Labrador Retriever was presented to the referring hospital with an acute onset (less than 1 day) of hematemesis and melena. The dog was treated supportively for a presumptive gastric ulcer for 4 days with intravenous fluids, gastro protectants, such as pantoprazole, misoprostol, sucralfate, and barium, as well as an anti-emetic (maropitant) and analgesics (fentanyl, gabapentin, and tramadol). Throughout medical management, the dog continued to require blood transfusions approximately every 24 h. Given the poor medical response, the patient was subjected to an exploratory laparotomy. During surgery, a grossly raised, blister-like lesion on the mucosal surface of the stomach was appreciated on the lesser curvature of the stomach. A partial gastrectomy was performed, and the segment was submitted for histological evaluation. Histologically, there were multiple, tortuous, medium-caliber muscular arteries (>1.0 mm in diameter) in the submucosa. A single large-caliber artery (>0.75 mm in diameter) containing a partially occlusive thrombus extruded through the mucosa and projected on the ulcerated surface. The patient\'s signs were similar clinically and histopathologically to Dieulafoy\'s lesion in people. A Dieulafoy\'s lesion is a potentially life-threatening disorder that causes gastrointestinal (GI) hemorrhage. This lesion is characterized by a dilated, large-caliber, aberrant submucosal artery that erodes through the epithelium and ruptures, resulting in massive and potentially fatal hemorrhage. This lesion has never been documented previously in a dog.
摘要：
一个大约12岁的孩子，31公斤，男性绝育的拉布拉多寻回犬被送往转诊医院，急性发作（少于1天），出现呕血和黑便。用静脉输液对狗进行了4天的支持性胃溃疡治疗，胃保护剂,比如泮托拉唑,米索前列醇,硫糖铝，和钡，以及止吐药（马洛皮坦）和镇痛药（芬太尼，加巴喷丁,和曲马多)。在整个医疗管理中，狗继续大约每24小时需要输血。鉴于医疗反应不佳，患者接受了剖腹探查术。手术期间,一个粗暴的，胃粘膜表面的水疱样病变在胃的较小曲率上可见。进行了部分胃切除术，并将该部分提交给组织学评估。组织学上,有多个，曲折,粘膜下层的中等口径肌肉动脉（直径>1.0毫米）。单条大口径动脉（直径>0.75mm），含有部分闭塞性血栓，经粘膜挤压并突出于溃疡表面。患者的体征在临床和组织病理学上与Dieulafoy的病变相似。Dieulafoy病变是一种可能危及生命的疾病，可引起胃肠道（GI）出血。这个病变的特征是扩张，大口径,通过上皮侵蚀并破裂的异常粘膜下动脉，导致大量和可能致命的出血。以前从未在狗中记录过这种病变。
