PDF(Pubmed)
Abstract：
UNASSIGNED: Given the known side effects of opioids and the negative impact of these side effects on quality of life (QOL), there is a need for therapies that can reduce opioid intake and improve QOL in patients suffering from cancer pain. Scrambler therapy (ST) is a neuromodulatory therapy that has been shown to reduce cancer pain, but its effect on QOL is not well understood. This study intended to evaluate the efficacy of ST for enhancing QOL in cancer patients through minimising pain and opioid intake.
UNASSIGNED: This was a randomised controlled trial including 80 patients with head, neck and thoracic cancer. In both arms, patients were given pain management drugs following the WHO analgesic ladder for ten consecutive days. In the intervention arm each day ST was given. Pain, morphine intake, and QOL (WHOQOL-BREF) were assessed.
UNASSIGNED: All domains of QOL improved significantly in the intervention arm in comparison to the control arm. In comparison to baseline, pain improved in both the intervention and the control arm on day 10 and at follow-up. However, QOL significantly improved in the intervention arm, while morphine intake decreased. In the control arm, QOL deteriorated, while morphine intake increased.
UNASSIGNED: ST significantly improved QOL. Since the increase in QOL took place along with a significantly lower morphine intake, the improvement in QOL may not only be explained by lower pain scores but, also, by a reduced intake of morphine, because the lower dosages of morphine will decrease the likelihood of side effects associated with the drug.
UNASSIGNED: This was a randomised controlled trial including 80 patients with head, neck and thoracic cancer. In both arms, patients were given pain management drugs following the WHO analgesic ladder for ten consecutive days. In the intervention arm each day ST was given. Pain, morphine intake, and QOL (WHOQOL-BREF) were assessed.
UNASSIGNED: All domains of QOL improved significantly in the intervention arm in comparison to the control arm. In comparison to baseline, pain improved in both the intervention and the control arm on day 10 and at follow-up. However, QOL significantly improved in the intervention arm, while morphine intake decreased. In the control arm, QOL deteriorated, while morphine intake increased.
UNASSIGNED: ST significantly improved QOL. Since the increase in QOL took place along with a significantly lower morphine intake, the improvement in QOL may not only be explained by lower pain scores but, also, by a reduced intake of morphine, because the lower dosages of morphine will decrease the likelihood of side effects associated with the drug.
摘要：
未经评估：鉴于阿片类药物的已知副作用以及这些副作用对生活质量（QOL）的负面影响，对于患有癌症疼痛的患者,需要能够减少阿片类药物的摄入并改善生活质量的疗法.扰频疗法（ST）是一种神经调节疗法，已被证明可以减轻癌症疼痛，但它对QOL的影响还没有得到很好的理解。这项研究旨在评估ST通过减少疼痛和阿片类药物的摄入来提高癌症患者生活质量的功效。
未经评估：这是一项随机对照试验，包括80例患者，颈部和胸部癌症.在双臂中，患者按照WHO镇痛阶梯连续10天接受疼痛管理药物治疗.在干预组每天给予ST。疼痛,吗啡摄入量,和QOL（WHOQOL-BREF）进行评估。
UNASSIGNED：与对照组相比，干预组的QOL的所有领域均有显着改善。与基线相比，在第10天和随访时,干预组和对照组的疼痛均得到改善.然而,干预组QOL明显改善，而吗啡摄入量减少。在控制臂中，QOL恶化，而吗啡摄入量增加。
UNASSIGNED：ST显著改善了生活质量。由于生活质量的增加伴随着吗啡摄入量的显著降低，生活质量的改善不仅可以通过较低的疼痛评分来解释，还,通过减少吗啡的摄入量，因为较低剂量的吗啡会降低与药物相关的副作用的可能性。
未经评估：这是一项随机对照试验，包括80例患者，颈部和胸部癌症.在双臂中，患者按照WHO镇痛阶梯连续10天接受疼痛管理药物治疗.在干预组每天给予ST。疼痛,吗啡摄入量,和QOL（WHOQOL-BREF）进行评估。
UNASSIGNED：与对照组相比，干预组的QOL的所有领域均有显着改善。与基线相比，在第10天和随访时,干预组和对照组的疼痛均得到改善.然而,干预组QOL明显改善，而吗啡摄入量减少。在控制臂中，QOL恶化，而吗啡摄入量增加。
UNASSIGNED：ST显著改善了生活质量。由于生活质量的增加伴随着吗啡摄入量的显著降低，生活质量的改善不仅可以通过较低的疼痛评分来解释，还,通过减少吗啡的摄入量，因为较低剂量的吗啡会降低与药物相关的副作用的可能性。
