Abstract：
OBJECTIVE: To evaluate brain biometry and cortical development by neurosonography in fetuses with congenital heart defect (CHD) and evaluate differences among different type of CHD.
METHODS: In a prospective cross sectional study singleton fetus with CHD were matched with controls and grouped into two categories according to the predicted severity of cerebral arterial oxygen deficit induced by the CHD: Group A mildly reduced or normal and Group B moderately to severely reduced. Neurosonography was done at 30-33 weeks to obtain measurements of corpus callosum (CC), cerebellar vermis (CV), Sylvian fissure (SF) insula, parieto-occipital fissure (POF), and calcarine sulci fissures (CSF). All the neurosonographic parameters were adjusted by head circumference (HC).
RESULTS: A total of 78 fetuses with CHD (group A 30; group B 48) and 80 matched controls form uncomplicated pregnancies were considered. CHD fetuses have significantly smaller CC, CV, SF, and POF and bigger insula when compared to control fetuses. These differences are more marked in group B fetuses. These differences remained significant after correction for HC values.
CONCLUSIONS: Fetuses with CHD have an impaired cortical development and these variations are more evident in those with a predicted lower oxygen delivery to the brain.
METHODS: In a prospective cross sectional study singleton fetus with CHD were matched with controls and grouped into two categories according to the predicted severity of cerebral arterial oxygen deficit induced by the CHD: Group A mildly reduced or normal and Group B moderately to severely reduced. Neurosonography was done at 30-33 weeks to obtain measurements of corpus callosum (CC), cerebellar vermis (CV), Sylvian fissure (SF) insula, parieto-occipital fissure (POF), and calcarine sulci fissures (CSF). All the neurosonographic parameters were adjusted by head circumference (HC).
RESULTS: A total of 78 fetuses with CHD (group A 30; group B 48) and 80 matched controls form uncomplicated pregnancies were considered. CHD fetuses have significantly smaller CC, CV, SF, and POF and bigger insula when compared to control fetuses. These differences are more marked in group B fetuses. These differences remained significant after correction for HC values.
CONCLUSIONS: Fetuses with CHD have an impaired cortical development and these variations are more evident in those with a predicted lower oxygen delivery to the brain.
摘要：
目的：通过神经超声评估先天性心脏病（CHD）胎儿的脑生物测定和皮质发育，并评估不同类型CHD之间的差异。
方法：在一项前瞻性横断面研究中，将患有冠心病的单胎胎儿与对照组进行匹配，并根据冠心病引起的脑动脉血氧缺乏的预测严重程度分为两类：A组轻度降低或正常，B组中度至重度降低。在30-33周进行神经超声检查以获得call体（CC）的测量值，小脑Vermis（CV），西尔维安裂隙（SF）脑岛，顶枕骨裂(POF),和calcarine沟裂（CSF）。所有神经声像图参数均通过头围（HC）进行调整。
结果：考虑了78例CHD胎儿（A组30；B组48）和80例匹配的对照组无并发症妊娠。CHD胎儿的CC明显较小，CV,SF,与对照胎儿相比，POF和更大的脑岛。这些差异在B组胎儿中更为明显。这些差异在校正HC值后仍然显著。
结论：患有CHD的胎儿的皮质发育受损，这些变化在预测向大脑输送氧气较低的胎儿中更为明显。
方法：在一项前瞻性横断面研究中，将患有冠心病的单胎胎儿与对照组进行匹配，并根据冠心病引起的脑动脉血氧缺乏的预测严重程度分为两类：A组轻度降低或正常，B组中度至重度降低。在30-33周进行神经超声检查以获得call体（CC）的测量值，小脑Vermis（CV），西尔维安裂隙（SF）脑岛，顶枕骨裂(POF),和calcarine沟裂（CSF）。所有神经声像图参数均通过头围（HC）进行调整。
结果：考虑了78例CHD胎儿（A组30；B组48）和80例匹配的对照组无并发症妊娠。CHD胎儿的CC明显较小，CV,SF,与对照胎儿相比，POF和更大的脑岛。这些差异在B组胎儿中更为明显。这些差异在校正HC值后仍然显著。
结论：患有CHD的胎儿的皮质发育受损，这些变化在预测向大脑输送氧气较低的胎儿中更为明显。
