PDF(Pubmed)
Abstract：
UNASSIGNED: To use structural magnetic resonance imaging (3D-MRI) to evaluate the abnormal development of the cerebral cortex in infants with global developmental delay (GDD).
UNASSIGNED: The GDD group includes 67 infants aged between 112 and 699 days with global developmental delay and who underwent T1-weighted MRI scans in Shanxi Children\'s Hospital from December 2019 to March 2022. The healthy control (HC) group includes 135 normal developing infants aged between 88 and 725 days in Shanxi Children\'s Hospital from September 2020 to August 2021. Whole-brain T1-weighted MRI scans were carried out with a 3.0-T magnetic resonance scanner, which was later processed using InfantSurfer to perform MR image processing and cortical surface reconstruction. Two morphological features of the cortical surface of the 68 brain regions were computed, i.e., the cortical thickness (CT) and cortical surface area (SA), and compared between the GDD and HC groups.
UNASSIGNED: With regard to the CT, the HC group showed a rapid decrease at first and then a slow increase after birth, and the CT of the GDD group decreased slowly and then became relatively stable. The GDD group showed bilaterally higher hemispherical average CT than those in the HC group. In detail, for the left hemisphere, except in the entorhinal and temporal poles in which the average CT values of the two brain regions were lower than those of the HC group, the CT of the 26 brain regions in the GDD group was higher than those of the HC group (p < 0.05). For the right hemisphere, the CT of the entorhinal in the GDD group was lower than that in the HC group. Otherwise, the CT of the remaining 28 brain regions was higher than those in the HC group (p < 0.05). With regard to the SA, both groups showed a rapid increase after birth till 23 months and remained quite stable afterward. The GDD group shows lower SA bilaterally than that in the HC group. In detail, SA in the GDD group was lower in most cortical regions of both hemispheres than in the HC group (p < 0.05), except for the right temporal pole and entorhinal. When testing for brain asymmetry, we found that the HC group showed obvious asymmetry of CT and SA, while only a few cortical regions in the GDD group showed asymmetry.
UNASSIGNED: The GDD group includes 67 infants aged between 112 and 699 days with global developmental delay and who underwent T1-weighted MRI scans in Shanxi Children\'s Hospital from December 2019 to March 2022. The healthy control (HC) group includes 135 normal developing infants aged between 88 and 725 days in Shanxi Children\'s Hospital from September 2020 to August 2021. Whole-brain T1-weighted MRI scans were carried out with a 3.0-T magnetic resonance scanner, which was later processed using InfantSurfer to perform MR image processing and cortical surface reconstruction. Two morphological features of the cortical surface of the 68 brain regions were computed, i.e., the cortical thickness (CT) and cortical surface area (SA), and compared between the GDD and HC groups.
UNASSIGNED: With regard to the CT, the HC group showed a rapid decrease at first and then a slow increase after birth, and the CT of the GDD group decreased slowly and then became relatively stable. The GDD group showed bilaterally higher hemispherical average CT than those in the HC group. In detail, for the left hemisphere, except in the entorhinal and temporal poles in which the average CT values of the two brain regions were lower than those of the HC group, the CT of the 26 brain regions in the GDD group was higher than those of the HC group (p < 0.05). For the right hemisphere, the CT of the entorhinal in the GDD group was lower than that in the HC group. Otherwise, the CT of the remaining 28 brain regions was higher than those in the HC group (p < 0.05). With regard to the SA, both groups showed a rapid increase after birth till 23 months and remained quite stable afterward. The GDD group shows lower SA bilaterally than that in the HC group. In detail, SA in the GDD group was lower in most cortical regions of both hemispheres than in the HC group (p < 0.05), except for the right temporal pole and entorhinal. When testing for brain asymmetry, we found that the HC group showed obvious asymmetry of CT and SA, while only a few cortical regions in the GDD group showed asymmetry.
摘要：
UNASSIGNED：使用结构磁共振成像（3D-MRI）评估全球发育迟缓（GDD）婴儿的大脑皮层发育异常。
UNASSIGNED：GDD组包括67名年龄在112至699天之间的全球发育迟缓婴儿，他们于2019年12月至2022年3月在山西省儿童医院接受了T1加权MRI扫描。健康对照（HC）组包括2020年9月至2021年8月在山西省儿童医院的135名88至725天的正常发育婴儿。使用3.0T磁共振扫描仪进行全脑T1加权MRI扫描，后来使用InfantSurfer进行MR图像处理和皮质表面重建。计算了68个大脑区域的皮质表面的两个形态特征，即，皮质厚度（CT）和皮质表面积（SA），并在GDD和HC组之间进行比较。
未经授权：关于CT，HC组首先表现为快速下降，然后在出生后缓慢上升，GDD组的CT缓慢下降，然后相对稳定。GDD组显示两侧半球平均CT高于HC组。详细来说,对于左半球，除了内嗅极和颞极两个脑区的平均CT值低于HC组，GDD组26个脑区的CT高于HC组(p<0.05)。对于右半球，GDD组的内嗅CT低于HC组。否则,其余28个脑区的CT均高于HC组（p<0.05）。关于SA，两组在出生后至23个月均呈快速增加趋势，此后仍相当稳定。GDD组显示低于HC组的双侧SA。详细来说,GDD组的SA在两个半球的大部分皮质区域均低于HC组（p<0.05），除了右颞极和内嗅。当测试大脑不对称时，我们发现HC组表现出明显的CT和SA不对称性,而GDD组中只有少数皮质区域表现出不对称性。
UNASSIGNED：GDD组包括67名年龄在112至699天之间的全球发育迟缓婴儿，他们于2019年12月至2022年3月在山西省儿童医院接受了T1加权MRI扫描。健康对照（HC）组包括2020年9月至2021年8月在山西省儿童医院的135名88至725天的正常发育婴儿。使用3.0T磁共振扫描仪进行全脑T1加权MRI扫描，后来使用InfantSurfer进行MR图像处理和皮质表面重建。计算了68个大脑区域的皮质表面的两个形态特征，即，皮质厚度（CT）和皮质表面积（SA），并在GDD和HC组之间进行比较。
未经授权：关于CT，HC组首先表现为快速下降，然后在出生后缓慢上升，GDD组的CT缓慢下降，然后相对稳定。GDD组显示两侧半球平均CT高于HC组。详细来说,对于左半球，除了内嗅极和颞极两个脑区的平均CT值低于HC组，GDD组26个脑区的CT高于HC组(p<0.05)。对于右半球，GDD组的内嗅CT低于HC组。否则,其余28个脑区的CT均高于HC组（p<0.05）。关于SA，两组在出生后至23个月均呈快速增加趋势，此后仍相当稳定。GDD组显示低于HC组的双侧SA。详细来说,GDD组的SA在两个半球的大部分皮质区域均低于HC组（p<0.05），除了右颞极和内嗅。当测试大脑不对称时，我们发现HC组表现出明显的CT和SA不对称性,而GDD组中只有少数皮质区域表现出不对称性。
