PDF(Pubmed)
Abstract：
UNASSIGNED: the introduction of the point-of-care in HIV-1 viral load quantification appears to be a complementary strategy to the existing conventional system of the acceleration plan for the achievement of the three 90s in Senegal. The objective of this study was to evaluate the performance of the Xpert® HIV-1 viral load in the context of circulation of non-B, non-C subtypes.
UNASSIGNED: two hundred samples, were tested on Xpert® HIV-1 Viral Load using 1 ml of plasma in comparison to 600 μl on Abbott Real-time HIV-1 assay. The difference between viral load values was considered significant for Dlog <0.5 log copies/ml.
UNASSIGNED: a good correlation (r=0.985) was noted and confirmed using passing-bablok regression (slope 1.048; 95% CI: 1.036 to 1.069) for 188 samples with samples. A mean difference of 0.0075 log10 copies/ml for a 95% confidence interval (CI) of 0.002 log10 copies/ml to 0.013 log10 copies/ml was obtained. Sensitivity and specificity were respectively 93.6% and 93.5% at the threshold of 1.6 log10 copies/ml and 100% and 99% at the threshold of 3.0 log10 copies/ml.
UNASSIGNED: these results show that Xpert® HIV-1 Viral Load has excellent performance. In Senegal, and can be used for HIV viral load monitoring.
UNASSIGNED: two hundred samples, were tested on Xpert® HIV-1 Viral Load using 1 ml of plasma in comparison to 600 μl on Abbott Real-time HIV-1 assay. The difference between viral load values was considered significant for Dlog <0.5 log copies/ml.
UNASSIGNED: a good correlation (r=0.985) was noted and confirmed using passing-bablok regression (slope 1.048; 95% CI: 1.036 to 1.069) for 188 samples with samples. A mean difference of 0.0075 log10 copies/ml for a 95% confidence interval (CI) of 0.002 log10 copies/ml to 0.013 log10 copies/ml was obtained. Sensitivity and specificity were respectively 93.6% and 93.5% at the threshold of 1.6 log10 copies/ml and 100% and 99% at the threshold of 3.0 log10 copies/ml.
UNASSIGNED: these results show that Xpert® HIV-1 Viral Load has excellent performance. In Senegal, and can be used for HIV viral load monitoring.
摘要：
UNASSIGNED：在HIV-1病毒载量定量中引入即时护理似乎是对塞内加尔实现三个90年代加速计划的现有常规系统的补充策略。这项研究的目的是评估Xpert®HIV-1病毒载量在非B循环中的表现，非C亚型。
未经评估：200个样本，使用1ml血浆在Xpert®HIV-1病毒载量上进行测试,与600μl的Abbott实时HIV-1测定相比。对于Dlog<0.5log拷贝/ml,病毒载量值之间的差异被认为是显著的。
UNASSIGNED：对于188个样品和样品，使用passing-bablok回归（斜率1.048；95％CI：1.036至1.069）发现并证实了良好的相关性（r=0.985）。对于0.002log10拷贝/ml至0.013log10拷贝/ml的95%置信区间(CI),获得0.0075log10拷贝/ml的平均差。敏感性和特异性在1.6log10拷贝/ml的阈值下分别为93.6%和93.5%,在3.0log10拷贝/ml的阈值下分别为100%和99%。
UNASSIGNED：这些结果表明Xpert®HIV-1ViralLoad具有出色的性能。在塞内加尔，并可用于HIV病毒载量监测。
未经评估：200个样本，使用1ml血浆在Xpert®HIV-1病毒载量上进行测试,与600μl的Abbott实时HIV-1测定相比。对于Dlog<0.5log拷贝/ml,病毒载量值之间的差异被认为是显著的。
UNASSIGNED：对于188个样品和样品，使用passing-bablok回归（斜率1.048；95％CI：1.036至1.069）发现并证实了良好的相关性（r=0.985）。对于0.002log10拷贝/ml至0.013log10拷贝/ml的95%置信区间(CI),获得0.0075log10拷贝/ml的平均差。敏感性和特异性在1.6log10拷贝/ml的阈值下分别为93.6%和93.5%,在3.0log10拷贝/ml的阈值下分别为100%和99%。
UNASSIGNED：这些结果表明Xpert®HIV-1ViralLoad具有出色的性能。在塞内加尔，并可用于HIV病毒载量监测。
