PDF(Pubmed)
Abstract：
Cortical gyrification, as a specific measure derived from magnetic resonance imaging, remains understudied in mild traumatic brain injury (mTBI). Local gyrification index (lGI) and mean curvature are related measures indexing the patterned folding of the cortex,ml which reflect distinct properties of cortical morphology and geometry. Using both metrics, we examined cortical gyrification morphology in 59 adult males with mTBI (n = 29) versus those without (n = 30) mTBI in the subacute phase of injury (between 2 weeks and 3 months). The effect of IQ on lGI and brain-symptom relations were also examined. General linear models revealed greater lGI in mTBI versus controls in the frontal lobes bilaterally, but reduced lGI in mTBI of the left temporal lobe. An age-related decrease in lGI was found in numerous areas, with no significant group-by-age interaction effects observed. Including other factors (i.e., mTBI severity, symptoms, and IQ) in the lGI model yielded similar results with few exceptions. Mean curvature analyses depicted a significant group-by-age interaction with the absence of significant main effects of group or age. Our results suggest that cortical gyrification morphology is adversely affected by mTBI in both frontal and temporal lobes, which are thought of as highly susceptible regions to mTBI. These findings contribute to understanding the effects of mTBI on neuromorphological properties, such as alterations in cortical gyrification, which reflect underlying microstructural changes (i.e., apoptosis, neuronal number, or white matter alterations). Future studies are needed to infer causal relationships between micro- and macrostructural changes after an mTBI and investigate potential sex differences.
摘要：
皮质旋化，作为一种来自磁共振成像的具体措施，在轻度创伤性脑损伤（mTBI）中仍未得到充分研究。局部回转指数（lGI）和平均曲率是相关的指标，可指示皮质的图案折叠，毫升，反映皮质形态和几何形状的不同性质。使用这两个指标，我们在亚急性损伤期(2周至3个月)检查了59例mTBI成年男性(n=29)与无mTBI成年男性(n=30)的皮质旋化形态.还检查了智商对lGI和脑症状关系的影响。一般线性模型显示mTBI的lGI高于双侧额叶的对照，但左颞叶mTBI的lGI降低。在许多地区发现了与年龄相关的lGI下降，没有观察到显著的按年龄分组的交互作用。包括其他因素(即，mTBI严重性,症状,和IQ）在lGI模型中产生了类似的结果，几乎没有例外。平均曲率分析描绘了按年龄分组的显着相互作用，而没有组或年龄的显着主要影响。我们的结果表明，额叶和颞叶的mTBI会对皮质回旋形态产生不利影响，被认为是mTBI的高度易感区域。这些发现有助于理解mTBI对神经形态学特性的影响，比如皮质旋化的改变，反映潜在的微观结构变化(即，凋亡，神经元数量，或白质改变)。未来的研究需要推断mTBI后微观和宏观结构变化之间的因果关系，并调查潜在的性别差异。
