Abstract：
BACKGROUND: Coexistence of molar pregnancy with living fetus represents a challenge in diagnosis and treatment. The objective of this study to present the outcome of molar pregnancy with a coexisting living fetus who were managed in our University Hospital in the last 5 years.
METHODS: We performed a retrospective analysis of patients who presented with molar pregnancy with a coexisting living fetus to our Gestational Trophoblastic Clinic, Mansoura University, Egypt from September, 2015 to August, 2020. Clinical characteristics of the patients, maternal complications as well as fetal outcome were recorded. The patients and their living babies were also followed up at least 6 months after delivery.
RESULTS: Twelve pregnancies were analyzed. The mean maternal age was 26.0 (SD 4.1) years and the median parity was 1.0 (range 0-3). Duration of the pregnancies ranged from 14 to 36 weeks. The median serum hCG was 165,210.0 U/L (range 7662-1,200,000). Three fetuses survived outside the uterus (25%), one of them died after 5 months because of congenital malformations. Histologic diagnosis was available for 10 of 12 cases and revealed complete mole associated with a normal placenta in 6 cases (60%) and partial mole in 4 cases (40%). Maternal complications occurred in 6 cases (50%) with the most common was severe vaginal bleeding in 4 cases (33.3%). There was no significant association between B-hCG levels and maternal complications (P = 0.3).
CONCLUSIONS: Maternal and fetal outcomes of molar pregnancy with a living fetus are poor. Counseling the patients for termination of pregnancy may be required.
BACKGROUND: The study was approved by Institutional Research Board (IRB), Faculty of Medicine, Mansoura University (number: R.21.10.1492).
METHODS: We performed a retrospective analysis of patients who presented with molar pregnancy with a coexisting living fetus to our Gestational Trophoblastic Clinic, Mansoura University, Egypt from September, 2015 to August, 2020. Clinical characteristics of the patients, maternal complications as well as fetal outcome were recorded. The patients and their living babies were also followed up at least 6 months after delivery.
RESULTS: Twelve pregnancies were analyzed. The mean maternal age was 26.0 (SD 4.1) years and the median parity was 1.0 (range 0-3). Duration of the pregnancies ranged from 14 to 36 weeks. The median serum hCG was 165,210.0 U/L (range 7662-1,200,000). Three fetuses survived outside the uterus (25%), one of them died after 5 months because of congenital malformations. Histologic diagnosis was available for 10 of 12 cases and revealed complete mole associated with a normal placenta in 6 cases (60%) and partial mole in 4 cases (40%). Maternal complications occurred in 6 cases (50%) with the most common was severe vaginal bleeding in 4 cases (33.3%). There was no significant association between B-hCG levels and maternal complications (P = 0.3).
CONCLUSIONS: Maternal and fetal outcomes of molar pregnancy with a living fetus are poor. Counseling the patients for termination of pregnancy may be required.
BACKGROUND: The study was approved by Institutional Research Board (IRB), Faculty of Medicine, Mansoura University (number: R.21.10.1492).
摘要：
背景：磨牙妊娠与活胎共存对诊断和治疗提出了挑战。这项研究的目的是介绍过去5年在我们大学医院接受治疗的磨牙妊娠与共存的活胎儿的结局。
方法：我们对患有磨牙妊娠和共存的活胎的患者进行了回顾性分析，曼苏拉大学,埃及9月起,2015年8月,2020年。患者的临床特征，记录产妇并发症和胎儿结局.在分娩后至少6个月对患者及其活着的婴儿进行了随访。
结果：分析了12例妊娠。产妇平均年龄为26.0（SD4.1）岁，产次中位数为1.0（范围0-3）。怀孕时间为14至36周。血清hCG中位数为165,210.0U/L（范围7662-1,200,000）。三个胎儿在子宫外存活（25%），其中一人在5个月后因先天性畸形死亡。12例中有10例可以进行组织学诊断，其中6例（60％）与正常胎盘相关的完全葡萄胎和4例（40％）与部分葡萄胎相关。产妇并发症6例（50％），最常见的是严重阴道出血4例（33.3％）。B-hCG水平与母体并发症之间没有显着关联（P=0.3）。
结论：有活胎的磨牙妊娠的母婴结局较差。可能需要咨询患者终止妊娠。
背景：该研究获得了机构研究委员会（IRB）的批准，医学院,曼苏拉大学（编号：R.21.10.1492）。
方法：我们对患有磨牙妊娠和共存的活胎的患者进行了回顾性分析，曼苏拉大学,埃及9月起,2015年8月,2020年。患者的临床特征，记录产妇并发症和胎儿结局.在分娩后至少6个月对患者及其活着的婴儿进行了随访。
结果：分析了12例妊娠。产妇平均年龄为26.0（SD4.1）岁，产次中位数为1.0（范围0-3）。怀孕时间为14至36周。血清hCG中位数为165,210.0U/L（范围7662-1,200,000）。三个胎儿在子宫外存活（25%），其中一人在5个月后因先天性畸形死亡。12例中有10例可以进行组织学诊断，其中6例（60％）与正常胎盘相关的完全葡萄胎和4例（40％）与部分葡萄胎相关。产妇并发症6例（50％），最常见的是严重阴道出血4例（33.3％）。B-hCG水平与母体并发症之间没有显着关联（P=0.3）。
结论：有活胎的磨牙妊娠的母婴结局较差。可能需要咨询患者终止妊娠。
背景：该研究获得了机构研究委员会（IRB）的批准，医学院,曼苏拉大学（编号：R.21.10.1492）。
