Abstract：
OBJECTIVE: Postoperative pain relief is a critical issue for hip arthroscopy surgery (HAS). This study aimed to investigate the effect of preemptive non-steroidal anti-inflammatory drugs (NSAIDs) for postoperative analgesia in femoroacetabular impingement (FAI) patients receiving HAS.
METHODS: This multicenter, randomized, controlled study enrolled 204 FAI patients receiving HAS, then assigned them to preoperative (PRE, N = 103) or postoperative (POS, N = 101) group as a 1:1 ratio; the PRE group administrated NSAIDs from 24 h pre-surgery to day 7 (D7) post-surgery, while the POS group administrated NSAIDs from 12 h post-surgery to D7 post-surgery.
CONCLUSIONS: Pain at rest was reduced at D1 (p = 0.016) and D2 (p = 0.023); pain at movement was decreased at D1 (p = 0.002), D2 (p = 0.020), and D3 (p = 0.030) in the PRE group compared with POS group, but not at other time points (all p > 0.05). Patient\'s satisfaction was increased at D1 (p = 0.013) and D3 (p = 0.029) in the PRE group compared to the POS group, but not at D7 (p = 0.145). Pethidine was less consumed at D3 (p = 0.038) and D7 (p = 0.017) in the PRE group in contrast with the POS group. Harris hip scores were similar at D7 (p = 0.124), month 1 (M1) (p = 0.273), and M3 (p = 0.360) between groups. Adverse events incidence was similar between groups (all p > 0.05). Besides, subgroup analysis discovered that pain was not influenced by the types of NSAID in both groups (all p > 0.05).
CONCLUSIONS: Starting NSAIDs before HAS provides better short-term pain relief and improves patient\'s satisfaction compared with its postoperative utilization, while does not induce additional adverse events in FAI patients.
METHODS: This multicenter, randomized, controlled study enrolled 204 FAI patients receiving HAS, then assigned them to preoperative (PRE, N = 103) or postoperative (POS, N = 101) group as a 1:1 ratio; the PRE group administrated NSAIDs from 24 h pre-surgery to day 7 (D7) post-surgery, while the POS group administrated NSAIDs from 12 h post-surgery to D7 post-surgery.
CONCLUSIONS: Pain at rest was reduced at D1 (p = 0.016) and D2 (p = 0.023); pain at movement was decreased at D1 (p = 0.002), D2 (p = 0.020), and D3 (p = 0.030) in the PRE group compared with POS group, but not at other time points (all p > 0.05). Patient\'s satisfaction was increased at D1 (p = 0.013) and D3 (p = 0.029) in the PRE group compared to the POS group, but not at D7 (p = 0.145). Pethidine was less consumed at D3 (p = 0.038) and D7 (p = 0.017) in the PRE group in contrast with the POS group. Harris hip scores were similar at D7 (p = 0.124), month 1 (M1) (p = 0.273), and M3 (p = 0.360) between groups. Adverse events incidence was similar between groups (all p > 0.05). Besides, subgroup analysis discovered that pain was not influenced by the types of NSAID in both groups (all p > 0.05).
CONCLUSIONS: Starting NSAIDs before HAS provides better short-term pain relief and improves patient\'s satisfaction compared with its postoperative utilization, while does not induce additional adverse events in FAI patients.
摘要：
目的：术后疼痛缓解是髋关节镜手术（HAS）的关键问题。本研究旨在探讨超前非甾体抗炎药（NSAIDs）对股骨髋臼撞击（FAI）患者术后镇痛的影响。
方法：这个多中心，随机化，对照研究纳入了204名接受HAS的FAI患者，然后将它们分配到术前(PRE，N=103)或术后(POS，N=101）组，比例为1：1；PRE组在手术前24小时至手术后第7天（D7）给予NSAIDs，而POS组从术后12小时到术后D7给予NSAIDs。
结论：在D1（p=0.016）和D2（p=0.023）时，静息疼痛减轻；在D1（p=0.002）时，运动疼痛减轻。D2(p=0.020),与POS组相比，PRE组的D3（p=0.030），但在其他时间点没有（所有p>0.05）。与POS组相比，PRE组患者的满意度在D1（p=0.013）和D3（p=0.029）增加，但不是在D7（p=0.145）。与POS组相比，PRE组的D3（p=0.038）和D7（p=0.017）消耗较少。Harris髋关节评分在D7时相似（p=0.124），第1个月（M1）（p=0.273），组间M3（p=0.360）。两组不良事件发生率相似(均p>0.05)。此外,亚组分析发现，两组患者的疼痛均不受NSAID类型的影响（均p>0.05）。
结论：与术后使用相比，在HAS前开始使用NSAIDs可提供更好的短期疼痛缓解，并提高患者的满意度。而不会在FAI患者中引起其他不良事件。
方法：这个多中心，随机化，对照研究纳入了204名接受HAS的FAI患者，然后将它们分配到术前(PRE，N=103)或术后(POS，N=101）组，比例为1：1；PRE组在手术前24小时至手术后第7天（D7）给予NSAIDs，而POS组从术后12小时到术后D7给予NSAIDs。
结论：在D1（p=0.016）和D2（p=0.023）时，静息疼痛减轻；在D1（p=0.002）时，运动疼痛减轻。D2(p=0.020),与POS组相比，PRE组的D3（p=0.030），但在其他时间点没有（所有p>0.05）。与POS组相比，PRE组患者的满意度在D1（p=0.013）和D3（p=0.029）增加，但不是在D7（p=0.145）。与POS组相比，PRE组的D3（p=0.038）和D7（p=0.017）消耗较少。Harris髋关节评分在D7时相似（p=0.124），第1个月（M1）（p=0.273），组间M3（p=0.360）。两组不良事件发生率相似(均p>0.05)。此外,亚组分析发现，两组患者的疼痛均不受NSAID类型的影响（均p>0.05）。
结论：与术后使用相比，在HAS前开始使用NSAIDs可提供更好的短期疼痛缓解，并提高患者的满意度。而不会在FAI患者中引起其他不良事件。
