Abstract：
Aim: The aim of this study was to measure serum levels of methylarginine derivatives and related metabolites in patients with gout. Materials & methods: This study enrolled 100 patients with gout and 80 patients in the control group. Serum asymmetric dimethylarginine, symmetric dimethylarginine, L-N-monomethylarginine, arginine, homoarginine, citrulline and ornithine levels were measured with tandem mass spectrometry. Results: Serum ornithine, citrulline and total methylated arginine load levels were statistically significantly higher in patients with gout compared with the control group, while serum arginine and homoarginine levels and global arginine bioavailability ratio were statistically significantly lower. Conclusion: There may be an association between gout, methylarginine levels and hyperuricemia and increased risk of cardiovascular disease.
摘要：
目的：本研究的目的是测量痛风患者血清中甲基精氨酸衍生物和相关代谢产物的水平。材料与方法：本研究纳入痛风患者100例，对照组80例。血清不对称二甲基精氨酸，对称二甲基精氨酸，L-N-单甲基精氨酸,精氨酸高精氨酸，用串联质谱法测定瓜氨酸和鸟氨酸水平。结果：血清鸟氨酸，与对照组相比，痛风患者的瓜氨酸和总甲基化精氨酸负荷水平在统计学上明显更高，而血清精氨酸和高精氨酸水平和整体精氨酸生物利用度比在统计学上显著降低。结论：痛风之间可能存在关联，甲基精氨酸水平和高尿酸血症和心血管疾病风险增加。
