PDF(Pubmed)
Abstract：
Myocarditis is one of the complications reported with COVID-19 vaccines, particularly both Pfizer-BioNTech and Moderna vaccines. Most of the published data about this association come from case reports and series. Integrating the geographical data, clinical manifestations, and outcomes is therefore important in patients with myocarditis to better understand the disease. A thorough literature search was conducted in Cochrane library, PubMed, ScienceDirect, and Google Scholar for published literature till 30 March 2022. We identified 26 patients eligible from 29 studies; the data were pooled from these qualifying case reports and case series. Around 94% of patients were male in this study, the median age for onset of myocarditis was 22 years and 85% developed symptoms after the second dose. The median time of admission for patients to hospitals post-vaccination was three days and chest pain was the most common presenting symptom in these patients. Most patients had elevated troponin on admission and about 90% of patients had cardiac magnetic resonance imaging (CMR) that showed late gadolinium enhancement. All patients admitted with myocarditis were discharged home after a median stay of four days. Results from this current analysis show that post-mRNA vaccination myocarditis is mainly seen in young males after the second dose of vaccination. The pathophysiology of vaccine-induced myocarditis is not entirely clear and late gadolinium enhancement is a common finding on CMR in these patients that may indicate myocardial fibrosis or necrosis. Prognosis remains good and all patients recovered from myocarditis, however further studies are advisable to assess long-term prognosis of myocarditis.
摘要：
心肌炎是COVID-19疫苗报道的并发症之一，特别是辉瑞生物技术公司和Moderna疫苗。有关此关联的大多数已发布数据来自病例报告和系列。整合地理数据，临床表现，因此,对于心肌炎患者,结局对更好地了解该病非常重要.在Cochrane图书馆进行了彻底的文献检索，PubMed,ScienceDirect,以及截至2022年3月30日发表文献的谷歌学者。我们从29项研究中确定了26例符合条件的患者；数据来自这些符合条件的病例报告和病例系列。在这项研究中，大约94%的患者是男性，心肌炎的中位发病年龄为22岁,85%的患者在第二次给药后出现症状.接种疫苗后患者入院的中位时间为三天，胸痛是这些患者中最常见的症状。大多数患者入院时肌钙蛋白升高，约90％的患者进行了心脏磁共振成像（CMR），显示钆增强。所有入院的心肌炎患者在中位住院四天后出院。当前分析的结果表明，mRNA疫苗接种后心肌炎主要见于第二次疫苗接种后的年轻男性。疫苗诱导的心肌炎的病理生理学尚不完全清楚，在这些患者中，CMR的晚期钆增强是常见的发现，可能表明心肌纤维化或坏死。预后仍然良好，所有患者都从心肌炎中康复，然而,建议进一步研究以评估心肌炎的长期预后.
