Abstract：
Common Human Coronaviruses (HCoVs), such as NL63, HKU1, 229E, and OC43, induce respiratory tract infections worldwide. Epidemiological studies of HCoVs are of paramount importance because the disease burden and trajectory (in years) have not been well addressed in adults. Here, we aimed to describe the burden of HCoVs in a hospital setting over five years before the coronavirus disease 2019 pandemic. This was a retrospective study of patients (>18 years) between January 1, 2015, and January 1, 2020, whose respiratory specimens were tested by multiplex real-time polymerase chain reaction. In total, 7,861 respiratory samples (4,540 patients) were included, 38% of which tested positive for any respiratory virus. Of these, 212 (12.2%) samples were positive for HCoVs, and their co-infection with other respiratory viruses was 30.6%. Rhinovirus (27.6%) was the most common co-infection among all three HCoVs. The overall prevalence of HCoVs tended to be the highest in the winter (40.9%). Patients aged ≥60 years had the highest prevalence of overall HCoVs (39.7%). Given the duration and large sample size, this study from Turkey is one of the largest to date among adults in the literature. These epidemiological data and molecular surveillance of HCoVs have important implications for the control and prevention of respiratory infections.
摘要：
常见的人类冠状病毒（HCoV），如NL63、HKU1、229E、和OC43在全球范围内引起呼吸道感染。HCoV的流行病学研究至关重要，因为成年人的疾病负担和轨迹（以年为单位）尚未得到很好的解决。这里,我们的目的是描述2019年冠状病毒病大流行前5年医院环境中HCoV的负担.这是2015年1月1日至2020年1月1日的患者（>18岁）的回顾性研究，其呼吸道标本通过多重实时聚合酶链反应进行了测试。总的来说,包括7,861个呼吸样本（4,540名患者），其中38%的呼吸道病毒检测呈阳性。其中,212（12.2%）个样本的HCoV阳性，他们与其他呼吸道病毒的共感染率为30.6%。鼻病毒（27.6％）是所有三种HCoV中最常见的共感染。冬季HCoV的总体患病率最高（40.9％）。年龄≥60岁的患者总体HCoV的患病率最高（39.7%）。考虑到持续时间和大样本量，这项来自土耳其的研究是迄今为止文献中成年人中规模最大的研究之一。这些流行病学数据和HCoV的分子监测对控制和预防呼吸道感染具有重要意义。
