METHODS: We describe a smooth course of pregnancy, a good maternal outcome, and a good fetal outcome in three consecutive pregnancies for a 35-year-old Mediterranean woman with Alport syndrome over a 10-year duration. Although there was a nephrotic range of progressive proteinuria in all her pregnancies, there was a prompt drop in proteinuria within 2 weeks of her deliveries. She has constantly shown a normal serum creatinine level and a normal serum protein level in all her pregnancies. Apart from a single episode of asymptomatic hypertension in her second pregnancy at 34 weeks of gestation that returned to a normal range immediately after delivery, she was normotensive antenatally and postnatally. She gave birth by cesarean section to three healthy newborns.
CONCLUSIONS: A normal prepregnancy creatinine level and a mild range of proteinuria in a patient with normotension, who is not on any medication, are associated with good maternal and fetal outcomes. Furthermore, successful pregnancy that is followed by a normal renal function test might suggest a favorable outcome for any future pregnancy.
方法:我们描述了一个顺利的怀孕过程,良好的母性结果,一名35岁的地中海女性患有Alport综合征,持续10年,连续三次怀孕,胎儿结局良好。尽管她的所有怀孕都有肾病性的进行性蛋白尿,在分娩后2周内蛋白尿迅速下降.在所有怀孕中,她一直显示出正常的血清肌酐水平和正常的血清蛋白水平。除了在妊娠34周时第二次怀孕时一次无症状高血压发作外,分娩后立即恢复到正常范围,她产前和产后血压正常。她剖腹产了三个健康的新生儿。
结论:正常孕前肌酐水平和轻度蛋白尿的患者,没有服用任何药物的人,与良好的母体和胎儿结局有关。此外,成功妊娠后再进行正常肾功能检查,可能提示未来妊娠结局良好.