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Abstract：
Hepatitis C virus (HCV) infection causes hepatic and extrahepatic organ involvement. Chronic kidney disease (CKD) is a prevalent non-communicable disorder, accounting for significant morbidity and mortality worldwide. Acute kidney injury and CKD are not uncommon sequels of acute or chronic HCV infection. The pathogenesis of HCV-associated kidney injuries is not well explored. Excess cryoglobulin production occurs in HCV infection. The cryoglobulin may initiate immune complex-mediated vasculitis, inducing vascular thrombosis and inflammation due to cryoglobulin deposits. Furthermore, direct damage to nephron parts also occurs in HCV patients. Other contributory causes such as hypertension, diabetes, and genetic polymorphism enhance the risk of kidney damage in HCV-infected individuals. Implementing CKD prevention, regular evaluation, and therapy may improve the HCV burden of kidney damage and its related outcomes. Therefore, in this review, we discuss and update the possible mechanism(s) of kidney injury pathogenesis with HCV infection. We searched for related published articles in EMBASE, Google Scholar, Google, PubMed, and Scopus. We used various texts and phrases, including hepatitis virus and kidney, HCV and CKD, kidney pathology in viral hepatitis, kidney transplantation in HCV-infected patients, kidney allograft survival in viral hepatitis patients, mechanism of kidney pathology in viral hepatitis, dialysis and viral hepatitis, HCV infection and kidney injuries, and viral hepatitis and CKD progression, etc. to identify relevant articles.
摘要：
丙型肝炎病毒（HCV）感染会导致肝脏和肝外器官受累。慢性肾脏病（CKD）是一种普遍的非传染性疾病，占世界范围内显著的发病率和死亡率。急性肾损伤和CKD是急性或慢性HCV感染的常见后遗症。HCV相关肾损伤的发病机制尚未得到很好的探讨。在HCV感染中发生过量的冷球蛋白产生。冷球蛋白可能引发免疫复合物介导的血管炎，诱导血管血栓形成和炎症由于冷球蛋白沉积。此外，对肾单位部分的直接损害也发生在HCV患者中。其他促成原因，如高血压，糖尿病,和遗传多态性增加HCV感染个体肾损害的风险。实施CKD预防，定期评估，治疗可以改善HCV的肾脏损害负担及其相关结局。因此,在这次审查中,我们讨论和更新HCV感染肾损伤发病机制的可能机制。我们在EMBASE中搜索了相关发表的文章，谷歌学者，Google,PubMed,还有Scopus.我们使用了各种文本和短语，包括肝炎病毒和肾脏，HCV和CKD,病毒性肝炎的肾脏病理学，HCV感染患者的肾移植，病毒性肝炎患者的肾脏同种异体移植存活率，病毒性肝炎的肾脏病理机制，透析和病毒性肝炎，HCV感染和肾损伤，病毒性肝炎和CKD进展，等。确定相关文章。
