PDF(Pubmed)
Abstract：
UNASSIGNED: Non-alcoholic steatohepatitis (NASH) is associated with increased mortality and a high clinical burden. NASH adversely impacts patients\' health-related quality of life (HRQoL), but published data on the humanistic burden of disease are limited. This review aimed to summarise and critically evaluate studies reporting HRQoL or patient-reported outcomes (PROs) in populations with NASH and identify key gaps for further research.
UNASSIGNED: Medline, EMBASE, the Cochrane Library and PsycINFO were searched for English-language publications published from 2010 to 2021 that reported HRQoL/PRO outcomes of a population or subpopulation with NASH.
UNASSIGNED: Twenty-five publications covering 23 unique studies were identified. Overall, the data showed a substantial impact of NASH on HRQoL, particularly in terms of physical functioning and fatigue, with deterioration of physical and mental health as NASH progresses. Prevalent symptoms, including fatigue, abdominal pain, anxiety/depression, cognition problems, and poor sleep quality, adversely impact patients\' ability to work and perform activities of daily living and the quality of relationships. However, some patients fail to attribute symptoms to their disease because of a lack of patient awareness and education. NASH is associated with high rates of comorbidities such as obesity and type 2 diabetes, which contribute to reduced HRQoL. Studies were heterogeneous in terms of diagnostic methods, population, outcomes, follow-up time, and measures of HRQoL/utility. Most studies were rated \'moderate\' at quality assessment, and all evaluable studies had inadequate control of confounders.
UNASSIGNED: NASH is associated with a significant HRQoL burden that begins early in the disease course and increases with disease progression. More robust studies are needed to better understand the humanistic burden of NASH, with adequate adjustment for confounders that could influence outcomes.
UNASSIGNED: Non-alcoholic steatohepatitis (NASH) has a significant impact on quality of life, with individuals experiencing worse physical and mental health compared with the general population. NASH and its symptoms, which include tiredness, stomach pain, anxiety, depression, poor focus and memory, and impaired sleep, affect individuals\' relationships and ability to work and perform day-to-day tasks. However, not all patients are aware that their symptoms may be related to NASH. Patients would benefit from more education on their disease, and the importance of good social networks for patient health and well-being should be reinforced. More studies are needed to better understand the patient burden of NASH.
UNASSIGNED: Medline, EMBASE, the Cochrane Library and PsycINFO were searched for English-language publications published from 2010 to 2021 that reported HRQoL/PRO outcomes of a population or subpopulation with NASH.
UNASSIGNED: Twenty-five publications covering 23 unique studies were identified. Overall, the data showed a substantial impact of NASH on HRQoL, particularly in terms of physical functioning and fatigue, with deterioration of physical and mental health as NASH progresses. Prevalent symptoms, including fatigue, abdominal pain, anxiety/depression, cognition problems, and poor sleep quality, adversely impact patients\' ability to work and perform activities of daily living and the quality of relationships. However, some patients fail to attribute symptoms to their disease because of a lack of patient awareness and education. NASH is associated with high rates of comorbidities such as obesity and type 2 diabetes, which contribute to reduced HRQoL. Studies were heterogeneous in terms of diagnostic methods, population, outcomes, follow-up time, and measures of HRQoL/utility. Most studies were rated \'moderate\' at quality assessment, and all evaluable studies had inadequate control of confounders.
UNASSIGNED: NASH is associated with a significant HRQoL burden that begins early in the disease course and increases with disease progression. More robust studies are needed to better understand the humanistic burden of NASH, with adequate adjustment for confounders that could influence outcomes.
UNASSIGNED: Non-alcoholic steatohepatitis (NASH) has a significant impact on quality of life, with individuals experiencing worse physical and mental health compared with the general population. NASH and its symptoms, which include tiredness, stomach pain, anxiety, depression, poor focus and memory, and impaired sleep, affect individuals\' relationships and ability to work and perform day-to-day tasks. However, not all patients are aware that their symptoms may be related to NASH. Patients would benefit from more education on their disease, and the importance of good social networks for patient health and well-being should be reinforced. More studies are needed to better understand the patient burden of NASH.
摘要：
未经证实：非酒精性脂肪性肝炎（NASH）与死亡率增加和高临床负担相关。NASH对患者健康相关生活质量(HRQoL)产生不利影响，但是关于疾病的人文负担的公开数据是有限的。这篇综述旨在总结和严格评估NASH人群中报告HRQoL或患者报告结果（PRO）的研究，并确定进一步研究的关键差距。
未经批准：Medline，EMBASE,我们在Cochrane图书馆和PsycINFO中搜索了2010年至2021年出版的英文出版物,这些出版物报告了NASH患者人群或亚人群的HRQoL/PRO结局.
UNASSIGNED：确定了25篇出版物，涵盖了23项独特的研究。总的来说,数据显示NASH对HRQoL有重大影响，特别是在身体机能和疲劳方面，随着NASH的进展，身心健康恶化。常见症状,包括疲劳,腹痛,焦虑/抑郁,认知问题，睡眠质量差，对患者的工作能力和日常生活活动能力以及人际关系质量产生不利影响。然而,由于缺乏患者的意识和教育，一些患者未能将症状归因于他们的疾病。NASH与肥胖和2型糖尿病等合并症的高发率相关，这有助于降低HRQoL。就诊断方法而言，研究是异质的，人口,结果，随访时间,以及HRQoL/效用的衡量标准。大多数研究在质量评估中被评为“中等”，所有可评估的研究都对混杂因素控制不足.
UNASSIGNED：NASH与显著的HRQoL负担相关，在病程早期开始并随疾病进展而增加。需要更有力的研究来更好地了解NASH的人文负担，对可能影响结果的混杂因素进行充分调整。
UNASSIGNED：非酒精性脂肪性肝炎（NASH）对生活质量有重大影响，与普通人群相比，个人的身心健康状况更差。NASH及其症状，其中包括疲倦，胃痛,焦虑,抑郁症,注意力和记忆力差，睡眠受损，影响个人关系和工作和执行日常任务的能力。然而,并非所有患者都知道他们的症状可能与NASH有关.患者将从更多的疾病教育中受益，良好的社交网络对患者健康和福祉的重要性应该得到加强。需要更多的研究来更好地了解NASH的患者负担。
未经批准：Medline，EMBASE,我们在Cochrane图书馆和PsycINFO中搜索了2010年至2021年出版的英文出版物,这些出版物报告了NASH患者人群或亚人群的HRQoL/PRO结局.
UNASSIGNED：确定了25篇出版物，涵盖了23项独特的研究。总的来说,数据显示NASH对HRQoL有重大影响，特别是在身体机能和疲劳方面，随着NASH的进展，身心健康恶化。常见症状,包括疲劳,腹痛,焦虑/抑郁,认知问题，睡眠质量差，对患者的工作能力和日常生活活动能力以及人际关系质量产生不利影响。然而,由于缺乏患者的意识和教育，一些患者未能将症状归因于他们的疾病。NASH与肥胖和2型糖尿病等合并症的高发率相关，这有助于降低HRQoL。就诊断方法而言，研究是异质的，人口,结果，随访时间,以及HRQoL/效用的衡量标准。大多数研究在质量评估中被评为“中等”，所有可评估的研究都对混杂因素控制不足.
UNASSIGNED：NASH与显著的HRQoL负担相关，在病程早期开始并随疾病进展而增加。需要更有力的研究来更好地了解NASH的人文负担，对可能影响结果的混杂因素进行充分调整。
UNASSIGNED：非酒精性脂肪性肝炎（NASH）对生活质量有重大影响，与普通人群相比，个人的身心健康状况更差。NASH及其症状，其中包括疲倦，胃痛,焦虑,抑郁症,注意力和记忆力差，睡眠受损，影响个人关系和工作和执行日常任务的能力。然而,并非所有患者都知道他们的症状可能与NASH有关.患者将从更多的疾病教育中受益，良好的社交网络对患者健康和福祉的重要性应该得到加强。需要更多的研究来更好地了解NASH的患者负担。
