Abstract：
BACKGROUND: Motor cortex stimulation applied as a clinical treatment for neuropathic disorders for decades. With stimulation electrodes placed directly on the cortical surface, this neuromodulation method provides higher spatial resolution than other non-invasive therapies. Yet, the therapeutic effects reported were not in conformity with different syndromes. One of the main issues is that the stimulation parameters are always determined by clinical experience. The lack of understanding about how the stimulation current propagates in the cortex and various stimulation parameters and configurations obstruct the development of this method.
METHODS: In this study, we investigated the effect of different stimulation configurations on cortical responses to motor cortical stimulations using intrinsic optical imaging.
RESULTS: Our results showed that the cortical activation of electrical stimulation is not only related to the current density but also related to the propagation distance. Besides, stimulation configurations also affect the propagation of the stimulation current.
CONCLUSIONS: All these results provide preliminary experimental evidence for parameter and electrode configuration optimizations.
METHODS: In this study, we investigated the effect of different stimulation configurations on cortical responses to motor cortical stimulations using intrinsic optical imaging.
RESULTS: Our results showed that the cortical activation of electrical stimulation is not only related to the current density but also related to the propagation distance. Besides, stimulation configurations also affect the propagation of the stimulation current.
CONCLUSIONS: All these results provide preliminary experimental evidence for parameter and electrode configuration optimizations.
摘要：
背景：运动皮质刺激作为神经性疾病的临床治疗应用了数十年。刺激电极直接放在皮质表面,这种神经调节方法提供比其他非侵入性治疗更高的空间分辨率。然而，报告的治疗效果与不同的综合征不一致。主要问题之一是刺激参数总是由临床经验决定。缺乏对刺激电流如何在皮层中传播的理解以及各种刺激参数和配置阻碍了该方法的发展。
方法：在本研究中，我们使用固有光学成像研究了不同刺激配置对皮层对运动皮层刺激反应的影响.
结果：我们的结果表明，电刺激的皮层激活不仅与电流密度有关，而且与传播距离有关。此外,刺激配置也影响刺激电流的传播。
结论：所有这些结果为参数和电极配置优化提供了初步的实验证据。
方法：在本研究中，我们使用固有光学成像研究了不同刺激配置对皮层对运动皮层刺激反应的影响.
结果：我们的结果表明，电刺激的皮层激活不仅与电流密度有关，而且与传播距离有关。此外,刺激配置也影响刺激电流的传播。
结论：所有这些结果为参数和电极配置优化提供了初步的实验证据。
