PDF(Pubmed)
Abstract：
Fungal infections are global public health problems and can lead to substantial human morbidity and mortality. Current antifungal therapy is not satisfactory, especially for invasive, life-threatening fungal infections. Modulating the antifungal capacity of the host immune system is a feasible way to combat fungal infections. Neutrophils are key components of the innate immune system that resist fungal pathogens by releasing reticular extracellular structures called neutrophil extracellular traps (NETs). When compared with phagocytosis and oxidative burst, NETs show better capability in terms of trapping large pathogens, such as fungi. This review will summarize interactions between fungal pathogens and NETs. Molecular mechanisms of fungi-induced NETs formation and defensive strategies used by fungi are also discussed.
摘要：
真菌感染是全球公共卫生问题，可导致大量人类发病率和死亡率。目前的抗真菌治疗并不令人满意，特别是对于侵入性，危及生命的真菌感染.调节宿主免疫系统的抗真菌能力是对抗真菌感染的可行方法。中性粒细胞是通过释放称为中性粒细胞胞外陷阱（NETs）的网状胞外结构来抵抗真菌病原体的先天免疫系统的关键成分。与吞噬作用和氧化爆发相比，NET在捕获大型病原体方面表现出更好的能力，如真菌。本文将总结真菌病原体与NETs之间的相互作用。还讨论了真菌诱导的NETs形成的分子机制和真菌使用的防御策略。
