Abstract：
Our aim was to describe the clinical profile of patients with idiopathic intracranial hypertension (IIH), assess ophthalmological manifestations, and correlate grade of papilledema with optic nerve sheath diameter (ONSD) and cerebrospinal fluid (CSF) opening pressure.
This was a prospective cross-sectional study. Patients between 18 and 60 years, diagnosed with IIH using modified Dandy criteria were included. Demographic details, ocular symptoms and signs were noted and papilledema graded. Ocular investigations such as B-scan ONSD and perimetry findings were noted for analysis.
The study included 32 patients of mean age 35.25(±9.57) years with a predominantly female population (96.9%). Mean BMI was 28.12(±5.32) kg/m2. Common presenting complaint was headache (87.5%). The most common gynecological disorder was dysmenorrhea (15.6%). Vitamin D deficiency (46.9%) was a biochemical abnormality seen. Most patients had BCVA 6/6 (62.5%). Lateral rectus palsy was present in 12.5%. Papilledema was present in 81.3% eyes with 31.3% Grade I. There was visual field loss in 53.1%, with 20.3% Grade I. Mean CSF opening pressure was 376.3(±191.51) mmH2O. MRI showed empty sella (34.4%) and tortuous optic nerve (18.8%). MRV showed transverse sinus stenosis (52.4%) as common abnormality. There was significant correlation between grade of papilledema and B-scan ONSD. No correlation was seen between CSF opening pressure and ONSD, grade of papilledema and grade of visual field defect and CSF opening pressure with BMI.
Clinical profile of patients with IIH was an overweight female of child-bearing age with headache. Visual field examinations are essential in management and follow-up. B-scan ONSD is useful to quantify raised ICP.
This was a prospective cross-sectional study. Patients between 18 and 60 years, diagnosed with IIH using modified Dandy criteria were included. Demographic details, ocular symptoms and signs were noted and papilledema graded. Ocular investigations such as B-scan ONSD and perimetry findings were noted for analysis.
The study included 32 patients of mean age 35.25(±9.57) years with a predominantly female population (96.9%). Mean BMI was 28.12(±5.32) kg/m2. Common presenting complaint was headache (87.5%). The most common gynecological disorder was dysmenorrhea (15.6%). Vitamin D deficiency (46.9%) was a biochemical abnormality seen. Most patients had BCVA 6/6 (62.5%). Lateral rectus palsy was present in 12.5%. Papilledema was present in 81.3% eyes with 31.3% Grade I. There was visual field loss in 53.1%, with 20.3% Grade I. Mean CSF opening pressure was 376.3(±191.51) mmH2O. MRI showed empty sella (34.4%) and tortuous optic nerve (18.8%). MRV showed transverse sinus stenosis (52.4%) as common abnormality. There was significant correlation between grade of papilledema and B-scan ONSD. No correlation was seen between CSF opening pressure and ONSD, grade of papilledema and grade of visual field defect and CSF opening pressure with BMI.
Clinical profile of patients with IIH was an overweight female of child-bearing age with headache. Visual field examinations are essential in management and follow-up. B-scan ONSD is useful to quantify raised ICP.
摘要：
我们的目的是描述特发性颅内高压（IIH）患者的临床特征，评估眼科表现，视神经鞘管直径（ONSD）和脑脊液（CSF）开放压力与视神经乳头水肿分级相关。
这是一项前瞻性横断面研究。18至60岁的患者，纳入使用改良Dandy标准诊断的IIH.人口统计细节，注意到眼部症状和体征，并对乳头水肿进行分级。注意到眼部调查，例如B扫描ONSD和视野检查结果进行分析。
该研究包括32名平均年龄35.25(±9.57)岁的患者，其中主要为女性（96.9%）。平均BMI为28.12(±5.32)kg/m2。常见的主诉是头痛（87.5%）。最常见的妇科疾病是痛经（15.6%）。维生素D缺乏（46.9％）是生化异常。大多数患者有BCVA6/6（62.5%）。侧直肌麻痹占12.5%。81.3％的眼睛存在乳头状水肿，31.3％的I级存在视野损失53.1％，具有20.3%的I级平均CSF开放压力为376.3(±191.51)mmH2O。MRI显示鞍空（34.4％）和弯曲的视神经（18.8％）。MRV常见异常为横窦狭窄（52.4%）。乳头水肿的分级与B扫描ONSD之间存在显着相关性。脑脊液开放压力和ONSD之间没有相关性，视神经乳头水肿分级、视野缺损分级、脑脊液开放压力与BMI的关系。
IIH患者的临床特征是一名超重的育龄女性，患有头痛。视野检查在管理和随访中至关重要。B扫描ONSD可用于量化升高的ICP。
这是一项前瞻性横断面研究。18至60岁的患者，纳入使用改良Dandy标准诊断的IIH.人口统计细节，注意到眼部症状和体征，并对乳头水肿进行分级。注意到眼部调查，例如B扫描ONSD和视野检查结果进行分析。
该研究包括32名平均年龄35.25(±9.57)岁的患者，其中主要为女性（96.9%）。平均BMI为28.12(±5.32)kg/m2。常见的主诉是头痛（87.5%）。最常见的妇科疾病是痛经（15.6%）。维生素D缺乏（46.9％）是生化异常。大多数患者有BCVA6/6（62.5%）。侧直肌麻痹占12.5%。81.3％的眼睛存在乳头状水肿，31.3％的I级存在视野损失53.1％，具有20.3%的I级平均CSF开放压力为376.3(±191.51)mmH2O。MRI显示鞍空（34.4％）和弯曲的视神经（18.8％）。MRV常见异常为横窦狭窄（52.4%）。乳头水肿的分级与B扫描ONSD之间存在显着相关性。脑脊液开放压力和ONSD之间没有相关性，视神经乳头水肿分级、视野缺损分级、脑脊液开放压力与BMI的关系。
IIH患者的临床特征是一名超重的育龄女性，患有头痛。视野检查在管理和随访中至关重要。B扫描ONSD可用于量化升高的ICP。
