Abstract：
UNASSIGNED: Currently, antibiotic treatment is often a standard dosing regimen in bone and joint infections (BJI). However, it remains unknown if exposure at the target-site is adequate. The aim of this review is to gain more insight in the relationship between the target site concentration of antibiotic and the minimal inhibitory concentration to target the bacteria in bone and joint infections (BJI).
UNASSIGNED: A literature search was performed by Erasmus MC Medical library. Bone, bone tissue and synovial concentration of antibiotics were covered in humans. In addition, we reported number of patients, dose, sampling method, analytical method and tissue and plasma concentrations. We used the epidemiological cutoff value (ECOFF) values of the targeted micro-organisms. If more than 3 publications were available on the antibiotic, we graphically presented ECOFFS values against reported antibiotic concentrations.
UNASSIGNED: For most antibiotics, the literature is sparse. In addition, a lot of variable and total antibiotic concentrations are published. Ciprofloxacin, cefazolin, cefuroxime, vancomycin and linezolid seem to have adequate average exposure if correlating total concentration to ECOFF, when standard dosing is used. With regard to other antibiotics, results are inconclusive. More extensive pharmacokinetic/pharmacodynamic modeling in BJI is needed.
UNASSIGNED: A literature search was performed by Erasmus MC Medical library. Bone, bone tissue and synovial concentration of antibiotics were covered in humans. In addition, we reported number of patients, dose, sampling method, analytical method and tissue and plasma concentrations. We used the epidemiological cutoff value (ECOFF) values of the targeted micro-organisms. If more than 3 publications were available on the antibiotic, we graphically presented ECOFFS values against reported antibiotic concentrations.
UNASSIGNED: For most antibiotics, the literature is sparse. In addition, a lot of variable and total antibiotic concentrations are published. Ciprofloxacin, cefazolin, cefuroxime, vancomycin and linezolid seem to have adequate average exposure if correlating total concentration to ECOFF, when standard dosing is used. With regard to other antibiotics, results are inconclusive. More extensive pharmacokinetic/pharmacodynamic modeling in BJI is needed.
摘要：
未经评估：目前，抗生素治疗通常是骨和关节感染(BJI)的标准给药方案.然而,目前尚不清楚目标部位的暴露是否足够。这篇综述的目的是更深入地了解抗生素的靶位浓度与骨和关节感染（BJI）中靶向细菌的最小抑制浓度之间的关系。
UNASSIGNED：ErasmusMC医学图书馆进行了文献检索。骨头,人体的骨组织和滑膜抗生素浓度均被覆盖.此外,我们报告了患者的数量，剂量,抽样方法，分析方法以及组织和血浆浓度。我们使用了目标微生物的流行病学临界值（ECOFF）。如果有超过3种抗生素出版物，我们以图形方式呈现了ECOFFS值相对于报告的抗生素浓度.
未经批准：对于大多数抗生素，文献稀疏。此外,发表了许多可变的和总的抗生素浓度。环丙沙星,头孢唑啉,头孢呋辛,万古霉素和利奈唑胺似乎有足够的平均暴露量，如果将总浓度与ECOFF相关联，当使用标准剂量时。关于其他抗生素，结果尚无定论。在BJI中需要更广泛的药代动力学/药效学建模。
UNASSIGNED：ErasmusMC医学图书馆进行了文献检索。骨头,人体的骨组织和滑膜抗生素浓度均被覆盖.此外,我们报告了患者的数量，剂量,抽样方法，分析方法以及组织和血浆浓度。我们使用了目标微生物的流行病学临界值（ECOFF）。如果有超过3种抗生素出版物，我们以图形方式呈现了ECOFFS值相对于报告的抗生素浓度.
未经批准：对于大多数抗生素，文献稀疏。此外,发表了许多可变的和总的抗生素浓度。环丙沙星,头孢唑啉,头孢呋辛,万古霉素和利奈唑胺似乎有足够的平均暴露量，如果将总浓度与ECOFF相关联，当使用标准剂量时。关于其他抗生素，结果尚无定论。在BJI中需要更广泛的药代动力学/药效学建模。
