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Abstract：
UNASSIGNED: Heparin-induced thrombocytopenia (HIT) is an immune-mediated complication that occurs in a small percentage of patients exposed to heparin. Concerns of HIT are particularly high in patients undergoing cardiac procedures requiring cardiopulmonary bypass, as they are exposed to high doses of heparin intraoperatively. Our aim was to identify and assess the hospital courses of patients who were diagnosed with HIT during readmission following cardiac surgery.
UNASSIGNED: A retrospective review of patients who underwent open cardiac surgical procedures from June 2017 through October 2019 was performed. Of these, we identified patients who were newly diagnosed with HIT upon readmission. HIT positivity was defined as a positive anti-PF4 antibody screening test, plus a positive serotonin release assay.
UNASSIGNED: Of the 2496 patients identified, 13 patients were HIT positive on index admission and were excluded. Of the remaining 2483 patients, 351 were readmitted within 30 days. Six were newly diagnosed with HIT during readmission, 5 of whom presented with thrombotic complications. One patient was readmitted with thrombocytopenia and was started on argatroban; the remaining 5 did not have a significantly lower platelet count on readmission. Of the 12 patients readmitted for venous thromboembolism, 4 tested positive for HIT.
UNASSIGNED: HIT can have a delayed appearance following open heart surgery. Venous thromboembolism appears to be a significant indicator for HIT during readmission, even in the absence of thrombocytopenia. This may support the use of non-heparin anticoagulation for cardiac surgery patients readmitted with thromboembolism until HIT status is determined.
UNASSIGNED: A retrospective review of patients who underwent open cardiac surgical procedures from June 2017 through October 2019 was performed. Of these, we identified patients who were newly diagnosed with HIT upon readmission. HIT positivity was defined as a positive anti-PF4 antibody screening test, plus a positive serotonin release assay.
UNASSIGNED: Of the 2496 patients identified, 13 patients were HIT positive on index admission and were excluded. Of the remaining 2483 patients, 351 were readmitted within 30 days. Six were newly diagnosed with HIT during readmission, 5 of whom presented with thrombotic complications. One patient was readmitted with thrombocytopenia and was started on argatroban; the remaining 5 did not have a significantly lower platelet count on readmission. Of the 12 patients readmitted for venous thromboembolism, 4 tested positive for HIT.
UNASSIGNED: HIT can have a delayed appearance following open heart surgery. Venous thromboembolism appears to be a significant indicator for HIT during readmission, even in the absence of thrombocytopenia. This may support the use of non-heparin anticoagulation for cardiac surgery patients readmitted with thromboembolism until HIT status is determined.
摘要：
UNASSIGNED：肝素诱导的血小板减少症（HIT）是一种免疫介导的并发症，发生在一小部分暴露于肝素的患者中。在接受需要体外循环的心脏手术的患者中，HIT的担忧尤其高，因为他们在术中接触高剂量的肝素。我们的目的是确定和评估在心脏手术后再次入院期间被诊断为HIT的患者的住院过程。
UNASSIGNED：对2017年6月至2019年10月接受心脏直视手术的患者进行了回顾性回顾。其中,我们确定了重新入院后新诊断为HIT的患者.HIT阳性定义为抗PF4抗体筛查试验阳性，加上血清素释放试验阳性。
未经证实：在确定的2496名患者中，13例患者入院时HIT阳性，被排除在外。在剩下的2483名患者中，351人在30天内再次入院。六人在重新入院期间被新诊断为HIT，其中5人出现血栓性并发症。一名患者因血小板减少症再次入院，并开始服用阿加曲班；其余5名患者在再次入院时血小板计数没有明显降低。在因静脉血栓栓塞再次入院的12例患者中,4检测为HIT阳性。
未经证实：HIT在心脏直视手术后可能出现延迟。静脉血栓栓塞似乎是再入院期间HIT的重要指标，即使没有血小板减少症。这可能支持在确定HIT状态之前，再次接受血栓栓塞的心脏手术患者使用非肝素抗凝药物。
UNASSIGNED：对2017年6月至2019年10月接受心脏直视手术的患者进行了回顾性回顾。其中,我们确定了重新入院后新诊断为HIT的患者.HIT阳性定义为抗PF4抗体筛查试验阳性，加上血清素释放试验阳性。
未经证实：在确定的2496名患者中，13例患者入院时HIT阳性，被排除在外。在剩下的2483名患者中，351人在30天内再次入院。六人在重新入院期间被新诊断为HIT，其中5人出现血栓性并发症。一名患者因血小板减少症再次入院，并开始服用阿加曲班；其余5名患者在再次入院时血小板计数没有明显降低。在因静脉血栓栓塞再次入院的12例患者中,4检测为HIT阳性。
未经证实：HIT在心脏直视手术后可能出现延迟。静脉血栓栓塞似乎是再入院期间HIT的重要指标，即使没有血小板减少症。这可能支持在确定HIT状态之前，再次接受血栓栓塞的心脏手术患者使用非肝素抗凝药物。
