PDF(Pubmed)
Abstract：
Capecitabine has been used for triple-negative metastatic breast cancers both as monotherapy and in combination with other agents. However, its gastrointestinal side effects are one of the biggest challenges for its patient compliance, and often result in permanent drug withdrawal. There have been reports of it causing enterocolitis (mainly terminal ileitis) and even ischaemic colitis, but it has not frequently been directly associated with Clostridium difficile infection. We describe a case of a 65-year-old woman with triple-negative breast cancer on palliative capecitabine who presented with blood-streaked watery diarrhea and abdominal pain and was diagnosed with chemotherapy-induced severe colitis with superimposed Clostridium difficile infection.
摘要：
卡培他滨已作为单一疗法和与其他药物组合用于三阴性转移性乳腺癌。然而,它的胃肠道副作用是患者依从性的最大挑战之一，并经常导致永久性停药。有报道说它会引起小肠结肠炎（主要是末端回肠炎），甚至是缺血性结肠炎，但它并不经常与艰难梭菌感染直接相关。我们描述了一例接受姑息性卡培他滨治疗的65岁三阴性乳腺癌妇女，该妇女出现血斑水样腹泻和腹痛，并被诊断为化疗引起的严重结肠炎并伴有艰难梭菌感染。
