UNASSIGNED: This was a retrospective study from a multihospital healthcare system including patients undergoing isolated CABG between 2011 and 2018. Patients were stratified by the presence of sCAS (≥80% stenosis) in at least 1 carotid artery. Perioperative and 5-year stroke were compared, and multivariable analysis was used to identify risk-adjusted predictors of stroke and mortality.
UNASSIGNED: A total of 5475 patients were included, 459 (8.4%) with sCAS and 5016 (91.6%) without sCAS. Patients with sCAS experienced more frequent perioperative stroke (4.4% vs 1.2%; P < .001), with most attributable to ischemic or embolic etiologies. The median duration of follow-up was 4.6 years (interquartile range, 3.0-6.5 years). One-year and 5-year survival were both lower in patients with sCAS (P < .001). In multivariable analysis, sCAS was associated with increased risk-adjusted hazard for both mortality (hazard ratio [HR], 1.28; 95% confidence interval [CI], 1.02-1.60; P = .030) and stroke (HR, 1.76; 95% CI, 1.20-2.59; P = .004). The strongest risk-adjusted predictor for stroke was a previous history of stroke (HR, 2.51; 95% CI, 1.77-3.55; P < .001).
UNASSIGNED: This contemporary analysis of CABG procedures reveals that concurrent sCAS continues to confer a significant stroke risk, especially in those with history of previous stroke. Although whether sCAS lesions are responsible for most strokes is unclear, they likely serve as a surrogate for other stroke risk factors.
UNASSIGNED:这是一项来自多医院医疗保健系统的回顾性研究,其中包括2011年至2018年接受隔离CABG的患者。根据至少1条颈动脉中存在sCAS(≥80%狭窄)对患者进行分层。比较围手术期和5年卒中,多变量分析用于确定卒中和死亡率的风险校正预测因子.
未经授权:共纳入5475例患者,有sCAS的459(8.4%)和无sCAS的5016(91.6%)。sCAS患者的围手术期卒中发生率更高(4.4%vs1.2%;P<.001),主要归因于缺血性或栓塞病因。中位随访时间为4.6年(四分位间距,3.0-6.5年)。sCAS患者的1年和5年生存率均较低(P<0.001)。在多变量分析中,SCAS与两种死亡率的风险调整风险增加相关(风险比[HR],1.28;95%置信区间[CI],1.02-1.60;P=.030)和中风(HR,1.76;95%CI,1.20-2.59;P=.004)。中风的最强风险调整预测因子是以前的中风史(HR,2.51;95%CI,1.77-3.55;P<.001)。
UNASSIGNED:对CABG手术的当代分析显示,并发sCAS继续赋予显著的卒中风险,尤其是那些有中风史的人。尽管尚不清楚sCAS病变是否与大多数中风有关,它们可能作为其他卒中风险因素的替代.